The STING Signaling: A Novel Target for Central Nervous System Diseases.

IF 3.6 4区医学 Q3 CELL BIOLOGY

Cellular and Molecular Neurobiology Pub Date : 2025-04-07 DOI:10.1007/s10571-025-01550-4

Min Song, Jianxun Ren, Zhipeng Zhu, Zhaohui Yi, Chengyun Wang, Lirong Liang, Jiahui Tian, Guofu Mao, Guohua Mao, Min Chen

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引用次数: 0

Abstract

The canonical cyclic GMP-AMP (cGAMP) synthase (cGAS)-Stimulator of Interferon Genes (STING) pathway has been widely recognized as a crucial mediator of inflammation in many diseases, including tumors, infections, and tissue damage. STING signaling can also be activated in a cGAS- or cGAMP-independent manner, although the specific mechanisms remain unclear. In-depth studies on the structural and molecular biology of the STING pathway have led to the development of therapeutic strategies involving STING modulators and their targeted delivery. These strategies may effectively penetrate the blood-brain barrier (BBB) and target STING signaling in multiple central nervous system (CNS) diseases in humans. In this review, we outline both canonical and non-canonical pathways of STING activation and describe the general mechanisms and associations between STING activity and CNS diseases. Finally, we discuss the prospects for the targeted delivery and clinical application of STING agonists and inhibitors, highlighting the STING signaling pathway as a novel therapeutic target in CNS diseases.

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STING信号传导：中枢神经系统疾病的新靶点。

典型的环GMP-AMP （cGAMP）合成酶(cGAS)-干扰素基因刺激因子（STING）途径已被广泛认为是许多疾病（包括肿瘤、感染和组织损伤）炎症的关键介质。STING信号也可以以cGAS或cgamp独立的方式激活，尽管具体机制尚不清楚。对STING通路的结构和分子生物学的深入研究导致了涉及STING调节剂及其靶向递送的治疗策略的发展。这些策略可能有效地穿透血脑屏障（BBB）并靶向人类多种中枢神经系统（CNS）疾病的STING信号。在这篇综述中，我们概述了STING激活的规范和非规范途径，并描述了STING活性与中枢神经系统疾病之间的一般机制和关联。最后，我们讨论了STING激动剂和抑制剂的靶向递送和临床应用前景，强调了STING信号通路作为中枢神经系统疾病的新治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cellular and Molecular Neurobiology 生物-神经科学

CiteScore

7.70

自引率

0.00%

发文量

137

审稿时长

4-8 weeks

期刊介绍： Cellular and Molecular Neurobiology publishes original research concerned with the analysis of neuronal and brain function at the cellular and subcellular levels. The journal offers timely, peer-reviewed articles that describe anatomic, genetic, physiologic, pharmacologic, and biochemical approaches to the study of neuronal function and the analysis of elementary mechanisms. Studies are presented on isolated mammalian tissues and intact animals, with investigations aimed at the molecular mechanisms or neuronal responses at the level of single cells. Cellular and Molecular Neurobiology also presents studies of the effects of neurons on other organ systems, such as analysis of the electrical or biochemical response to neurotransmitters or neurohormones on smooth muscle or gland cells.