Impact of Equipment Material and Surface Finish on the Flowability of dry Cohesive Powders – an Important Consideration in Calibration of Discrete Element Models

IF 2.7 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Ankita Sharma, Jayanta Chakraborty, Anurag Tripathi, Jitendra Kumar, Maitraye Sen, William Ketterhagen
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引用次数: 0

Abstract

Discrete Element Method (DEM) simulations of cohesive particles are of great importance in understanding powder flows in processing equipment. Calibration of the particle–particle or particle–wall interaction parameters is important, and although there are many studies on DEM simulations of cohesive powders, most of them do not differentiate between particle–particle cohesive and particle–wall adhesive forces. In this work, a bench-top experimental setup was designed to demonstrate the effect of particle–wall adhesive forces. A simulation-based sensitivity analysis was also performed using a commercial scale tablet press feeder (TPF) and hopper screw feeder (HSF), by independently varying the particle–particle and particle–wall cohesive energy density values to illustrate their effect on powder flowability. Both the feeders experienced blockages for highly cohesive particles whose cohesive energy density exceeds 80 kJ/m3 in case of TPF and 110 kJ/m3 for HSF. The occurrence of such blockages was eliminated by reducing the particle–wall adhesion to 30 kJ/m3 in case of TPF and 50 kJ/m3 for HSF while keeping the particle–particle cohesion at the same high value. Thus, this work demonstrates that the particle–particle cohesion and particle wall adhesion should be considered as separate entities and must be calibrated separately in DEM so that the materials interaction effects of both powder and equipment can be captured adequately.

设备材料和表面光洁度对干燥粘性粉末流动性的影响——离散元模型校准中的一个重要考虑因素
离散元法(DEM)模拟黏结颗粒对于理解加工设备中的粉末流动具有重要意义。颗粒-颗粒或颗粒-壁相互作用参数的校准很重要,尽管有许多关于粘性粉末的DEM模拟研究,但大多数研究没有区分颗粒-颗粒粘性和颗粒-壁粘附力。在这项工作中,设计了一个台式实验装置来证明颗粒壁粘附力的影响。利用商业规模的压片给料机(TPF)和料斗螺旋给料机(HSF)进行了基于模拟的灵敏度分析,通过独立改变颗粒-颗粒和颗粒-壁的内聚能密度值来说明它们对粉末流动性的影响。两种给料器都发生了高粘性颗粒的堵塞,在TPF和HSF中,粘性能密度分别超过80 kJ/m3和110 kJ/m3。通过将TPF的颗粒-壁粘附力降低到30 kJ/m3, HSF降低到50 kJ/m3,同时保持颗粒-颗粒内聚力相同的高值,消除了这种堵塞的发生。因此,这项工作表明,颗粒-颗粒内聚和颗粒壁粘附应被视为独立的实体,必须在DEM中单独校准,以便充分捕捉粉末和设备的材料相互作用效应。
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来源期刊
Journal of Pharmaceutical Innovation
Journal of Pharmaceutical Innovation PHARMACOLOGY & PHARMACY-
CiteScore
3.70
自引率
3.80%
发文量
90
审稿时长
>12 weeks
期刊介绍: The Journal of Pharmaceutical Innovation (JPI), is an international, multidisciplinary peer-reviewed scientific journal dedicated to publishing high quality papers emphasizing innovative research and applied technologies within the pharmaceutical and biotechnology industries. JPI''s goal is to be the premier communication vehicle for the critical body of knowledge that is needed for scientific evolution and technical innovation, from R&D to market. Topics will fall under the following categories: Materials science, Product design, Process design, optimization, automation and control, Facilities; Information management, Regulatory policy and strategy, Supply chain developments , Education and professional development, Journal of Pharmaceutical Innovation publishes four issues a year.
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