Pediatric-onset multiple sclerosis in Greece: A single-center study of the risk factors and a review of the literature

IF 2.3 3区医学 Q3 CLINICAL NEUROLOGY

European Journal of Paediatric Neurology Pub Date : 2025-03-01 DOI:10.1016/j.ejpn.2025.04.001

Evangelia Bechlivani , Efterpi Pavlidou , Konstantinos Notas , Martha Spilioti , Panagiota Karananou , Evangelos Pavlou , Anastasios Orologas , Dimitrios Zafeiriou , Athanasios Evangeliou

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引用次数: 0

Abstract

Pediatric-onset multiple sclerosis (POMS) accounts for up to 10 % of the affected population. However, it remains an unexplored field in Greece, as no national registry or disease's atlas are currently available. Because of that, we conducted a single-center study. We searched the registries of our hospital during the period January 2010–September 2023 and catalogued 23 children that were under 16 years old when they were first hospitalized in our department and diagnosed with POMS. We compared our data collected to the available literature regarding demographics and the risk factors, and our findings in general meet the acquired POMS knowledge. Most of our children have vitamin D deficiency, previous EBV infection, whilst some of them have personal or family history of autoimmunity. The mean age of first diagnosis is 12.3 years, similar to the global mean age of POMS. Despite the findings obtained, more studies are essential in this field.

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希腊儿童发病多发性硬化症：危险因素的单中心研究和文献综述

儿科发病多发性硬化症（POMS）占受影响人口的10%。然而，在希腊，这仍然是一个未开发的领域，因为目前没有国家登记或疾病地图集。因此，我们进行了一项单中心研究。我们检索了我院2010年1月至2023年9月期间的登记资料，并对23名首次在我科住院并诊断为POMS的16岁以下儿童进行了编目。我们将收集到的数据与有关人口统计学和危险因素的现有文献进行了比较，我们的发现总体上符合已获得的POMS知识。我们的大多数孩子都有维生素D缺乏症，以前感染过EBV，而他们中的一些人有个人或家族自身免疫史。首次诊断的平均年龄为12.3岁，与全球POMS的平均年龄相似。尽管有了这些发现，但在这一领域还需要进行更多的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Paediatric Neurology 医学-临床神经学

CiteScore

6.30

自引率

3.20%

发文量

115

审稿时长

81 days

期刊介绍： The European Journal of Paediatric Neurology is the Official Journal of the European Paediatric Neurology Society, successor to the long-established European Federation of Child Neurology Societies. Under the guidance of a prestigious International editorial board, this multi-disciplinary journal publishes exciting clinical and experimental research in this rapidly expanding field. High quality papers written by leading experts encompass all the major diseases including epilepsy, movement disorders, neuromuscular disorders, neurodegenerative disorders and intellectual disability. Other exciting highlights include articles on brain imaging and neonatal neurology, and the publication of regularly updated tables relating to the main groups of disorders.