The use of indocyanine green (ICG) for sentinel lymph node detection in vulvar cancer

IF 4.5 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Gynecologic oncology Pub Date : 2025-04-09 DOI:10.1016/j.ygyno.2025.03.039

Karlijn M.C. Cornel , Meera P. Mehta , Brenna E. Swift , Allan Covens , Danielle Vicus , Rachel S. Kupets , Lilian T. Gien

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引用次数: 0

Abstract

Objective

The aim of this study is to evaluate the use of indocyanine green (ICG) as a detection modality in sentinel lymph node (SLN) procedures for vulvar cancer.

Method

A retrospective cohort study was performed from January 2008–August 2022 including all patients who underwent a SLN procedure for ≤4 cm vulvar cancer tumors with clinically/radiological normal inguinal nodes. SLN procedures with Tc99 +/− blue dye were compared to those with ICG +/− Tc99. Patient and tumor characteristics were collected as well as short-term and long-term complications. A subset analysis of SLN procedures with ICG alone was described.

Results

A total of 229 patients were included, representing 365 groins. Detection modality was Tc99 +/−blue dye in 189 patients (304 groins) and ICG +/-Tc99 in 40 patients (60 groins). The SLN detection rate for Tc99 +/− blue dye was 93.4 % and for ICG +/− Tc99 90.3 % (p = 0.4). The SLN was positive in 17.3 % of the Tc99 +/− blue dye group vs 23.2 % in the ICG +/− Tc99 group (p = 0.3). There was no significant difference in short- or long-term complications.

The detection rate among 15 patients (22 groins) where ICG was used as a single modality was 90.9 %. There were no specific patient or tumor characteristics related to SLN mapping failure.

Conclusion

The use of ICG +/− Tc99 as detection modality shows promising results with a success rate comparable to Tc99 +/− blue dye, supporting the use of ICG. Future studies are needed to confirm the efficacy and long-term safety of ICG alone.

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吲哚菁绿（ICG）在外阴癌前哨淋巴结检测中的应用

本研究旨在评估吲哚菁绿（ICG）在外阴癌前哨淋巴结（SLN）手术中作为一种检测方式的使用情况。方法 2008年1月至2022年8月期间进行了一项回顾性队列研究，研究对象包括所有因外阴癌肿瘤≤4厘米且腹股沟结节临床/放射学正常而接受SLN手术的患者。使用 Tc99 +/- 蓝色染料的 SLN 手术与使用 ICG +/- Tc99 的手术进行了比较。收集了患者和肿瘤特征以及短期和长期并发症。结果共纳入 229 名患者，代表了 365 个腹股沟。189 例患者（304 个腹股沟）的检测方式为 Tc99 +/ 蓝染料，40 例患者（60 个腹股沟）的检测方式为 ICG +/-Tc99。Tc99 +/- 蓝色染料的 SLN 检测率为 93.4%，ICG +/- Tc99 为 90.3%（p = 0.4）。Tc99+/-蓝色染料组中17.3%的SLN呈阳性，ICG+/-Tc99组中23.2%的SLN呈阳性（P = 0.3）。在 15 名患者（22 个腹股沟）中，ICG 作为单一方式的检出率为 90.9%。结论使用 ICG +/- Tc99 作为检测方式显示出良好的效果，其成功率与 Tc99 +/- 蓝色染料相当，支持使用 ICG。未来的研究需要证实 ICG 单独使用的有效性和长期安全性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gynecologic oncology 医学-妇产科学

CiteScore

8.60

自引率

6.40%

发文量

1062

审稿时长

37 days

期刊介绍： Gynecologic Oncology, an international journal, is devoted to the publication of clinical and investigative articles that concern tumors of the female reproductive tract. Investigations relating to the etiology, diagnosis, and treatment of female cancers, as well as research from any of the disciplines related to this field of interest, are published. Research Areas Include: • Cell and molecular biology • Chemotherapy • Cytology • Endocrinology • Epidemiology • Genetics • Gynecologic surgery • Immunology • Pathology • Radiotherapy