Nickel/Photo-Cocatalyzed Three-Component Silylarylation of Electron-Deficient Alkenes

IF 4.6 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2025-04-08 DOI:10.1039/d5qo00346f

Pei Fan, Xiao-Xue Huang

引用次数: 0

Abstract

Herein we report a nickel/photo-cocatalyzed silylarylation of electron-deficient alkenes with aryl bromides and hydrosilanes, providing new access to a variety of β-silyl-α-aryl propionates with good functionality tolerance. Tetrabutylammonium decatungstate-mediated chemoselective radical Si-H activation via hydrogen atom transfer, sila-Giese addition, and nickel-mediated C‒C bond formation constitute the key elementary steps of this process.

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镍/光共催化缺电子烯烃的三组分硅芳基化反应

本文报道了镍/光共催化的缺电子烯烃与芳基溴和氢硅烷的硅芳基酰化反应，为获得各种具有良好官能耐受性的β-硅基-α-芳基丙酸酯提供了新的途径。十钨酸四丁基铵通过氢原子转移、硅基加成和镍介导的C-C键形成介导的化学选择性自由基Si-H活化是这一过程的关键基本步骤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.