Volumetric and dosimetric comparison of computed tomography- and trans-abdominal ultrasound-based volumes for image-guided cervix cancer brachytherapy.

IF 1.1 4区 医学 Q4 ONCOLOGY
Journal of Contemporary Brachytherapy Pub Date : 2025-02-01 Epub Date: 2025-02-24 DOI:10.5114/jcb.2025.147944
Juan Carlos Pari Salas, Kevin Aguirre Urviola, Paola Cynthia Smith Benavides, Digna Cristina Santos Flores, Albert Bedregal Cruz, Danny Giancarlo Apaza Véliz
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引用次数: 0

Abstract

Purpose: In cervical cancer, brachytherapy is a key component of multi-disciplinary treatment. Wide scale studies, such as EMBRACE, demonstrate benefits of volume-oriented and image-guided brachytherapy. However, MRI and CT are too expensive for health systems with scarce resources. The aim of the study was to assess whether ultrasound- and CT-based volumes of high-risk clinical target volume (HR-CTV) in organs at risk (OARs) as well as dose values in a given plan are comparable.

Material and methods: Eighteen applications were evaluated. After CT scans, axial ultrasound images were acquired in 5 mm steps, serving as a secondary set. Post-prescription, HR-CTV, bladder, and rectum were contoured on ultrasound images. Image sets were compared using CT-based volumes as primary reference. Dice coefficient and Jaccard index were calculated. CT-based dosimetric plan was then compared with ultrasound-based volumes to determine D90 HR-CTV, D2cc bladder, and D2cc rectum, and these were compared with CT-based values.

Results: The mean dose differences between CT and ultrasound volumes for HR-CTV and D2cc rectum were less than 5%, with the bladder slightly above 5%. Wilcoxon test showed no significant difference between the mean doses for CT and ultrasound. Dice coefficients indicated good to very good correlation for these volumes.

Conclusions: Ultrasound-based volume acquisition appears comparable with CT volumetric acquisition in both dosimetric and volumetric terms. Further studies are needed to validate this technique, potentially offering a more affordable and feasible volume-based brachytherapy option for low-income health systems.

影像引导下宫颈癌近距离放射治疗中基于计算机断层扫描和经腹超声的体积和剂量比较。
目的:在宫颈癌中,近距离放疗是多学科治疗的重要组成部分。大规模的研究,如EMBRACE,证明了体积导向和图像引导的近距离治疗的好处。然而,对于资源稀缺的卫生系统来说,MRI和CT过于昂贵。该研究的目的是评估超声和ct在危险器官(OARs)中的高危临床靶体积(HR-CTV)以及给定方案中的剂量值是否具有可比性。材料与方法:对18项应用进行了评价。CT扫描后,以5毫米为步,获得轴向超声图像,作为第二组。处方后,HR-CTV,膀胱和直肠在超声图像上轮廓。使用基于ct的卷作为主要参考来比较图像集。计算骰子系数和Jaccard指数。然后将基于ct的剂量计划与基于超声的体积进行比较,以确定D90 HR-CTV,膀胱D2cc和直肠D2cc,并将这些与基于ct的值进行比较。结果:HR-CTV和D2cc直肠CT与超声体积的平均剂量差值小于5%,膀胱略高于5%。Wilcoxon试验显示CT和超声的平均剂量无显著差异。骰子系数表明这些体积具有良好到非常好的相关性。结论:在剂量学和体积学方面,基于超声的体积采集似乎与CT体积采集相当。需要进一步的研究来验证这种技术,为低收入卫生系统提供一种更实惠和可行的基于体积的近距离治疗选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Contemporary Brachytherapy
Journal of Contemporary Brachytherapy ONCOLOGY-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
CiteScore
2.40
自引率
14.30%
发文量
54
审稿时长
16 weeks
期刊介绍: The “Journal of Contemporary Brachytherapy” is an international and multidisciplinary journal that will publish papers of original research as well as reviews of articles. Main subjects of the journal include: clinical brachytherapy, combined modality treatment, advances in radiobiology, hyperthermia and tumour biology, as well as physical aspects relevant to brachytherapy, particularly in the field of imaging, dosimetry and radiation therapy planning. Original contributions will include experimental studies of combined modality treatment, tumor sensitization and normal tissue protection, molecular radiation biology, and clinical investigations of cancer treatment in brachytherapy. Another field of interest will be the educational part of the journal.
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