Cancer stem cell specificity as new targets in breast tumor treatment.

IF 4.1 4区医学 Q3 ONCOLOGY

Oncology Research Pub Date : 2025-03-19 eCollection Date: 2025-01-01 DOI:10.32604/or.2024.050505

Zhizheng Zhang, Tao Li, Yuan Li, X I Wang, Hao Liu, Xinyu Shen, Ann Xu, Tiansong Xia, B O Xu

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引用次数: 0

Abstract

Background: Breast cancer is a prevalent malignant tumor affecting females, with treatment options including surgery, radiotherapy, chemotherapy, and endocrine therapy.

Methods: This review synthesizes existing literature on breast cancer stem cells and their applications in breast cancer treatment. PubMed, Web of Science, and other relevant databases were systematically searched using keywords such as "breast cancer stem cells," "immunotherapy," "gene therapy," and "cell therapy." Studies published in English were included, and their findings were analyzed to provide insights into the characteristics and therapeutic potential of breast cancer stem cells.

Results: Breast cancer stem cells exhibit unique properties that contribute to tumor initiation, progression, recurrence, and therapy resistance. Immunotherapy targeting breast cancer stem cells shows promise in overcoming these challenges, but issues such as lack of specificity and drug resistance need to be addressed.

Conclusions: Breast cancer stem cells represent promising targets for innovative therapeutic strategies aimed at improving treatment outcomes in breast cancer patients.

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肿瘤干细胞特异性作为乳腺癌治疗的新靶点。

背景：乳腺癌是一种影响女性的常见恶性肿瘤，治疗方法包括手术、放疗、化疗和内分泌治疗。方法：对乳腺癌干细胞及其在乳腺癌治疗中的应用进行综述。使用“乳腺癌干细胞”、“免疫疗法”、“基因疗法”和“细胞疗法”等关键词系统地搜索PubMed、Web of Science和其他相关数据库。以英文发表的研究被纳入其中，他们的发现被分析，以提供对乳腺癌干细胞的特征和治疗潜力的见解。结果：乳腺癌干细胞表现出独特的特性，有助于肿瘤的发生、进展、复发和治疗抵抗。针对乳腺癌干细胞的免疫疗法有望克服这些挑战，但缺乏特异性和耐药性等问题需要解决。结论：乳腺癌干细胞代表了创新治疗策略的有希望的靶点，旨在改善乳腺癌患者的治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oncology Research 医学-肿瘤学

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： Oncology Research Featuring Preclinical and Clincal Cancer Therapeutics publishes research of the highest quality that contributes to an understanding of cancer in areas of molecular biology, cell biology, biochemistry, biophysics, genetics, biology, endocrinology, and immunology, as well as studies on the mechanism of action of carcinogens and therapeutic agents, reports dealing with cancer prevention and epidemiology, and clinical trials delineating effective new therapeutic regimens.