{"title":"HDL meets triglyceride.","authors":"Tugce Akcan, Fredric B Kraemer","doi":"10.1016/j.jlr.2025.100796","DOIUrl":null,"url":null,"abstract":"<p><p>The study by Liu et al in this issue of the Journal of Lipid Research leverages data from the UK Biobank to explore the impact of HDL-TG on atherosclerotic cardiovascular disease risk. The investigators observed that elevated serum triglyceride levels were associated with reduced HDL particle diameter and with increased HDL-TG. Using observational and Mendelian randomization analyses, HDL-TG levels were independently associated with atherosclerotic cardiovascular disease risk even after adjusting for multiple confounders and other risk factors. The results emphasize the need for a broader evaluation of lipid parameters that extends beyond traditional measurements and suggest that incorporating metrics like HDL-TG could enhance risk stratification.</p>","PeriodicalId":16209,"journal":{"name":"Journal of Lipid Research","volume":" ","pages":"100796"},"PeriodicalIF":5.0000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12127560/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Lipid Research","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.jlr.2025.100796","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/4 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The study by Liu et al in this issue of the Journal of Lipid Research leverages data from the UK Biobank to explore the impact of HDL-TG on atherosclerotic cardiovascular disease risk. The investigators observed that elevated serum triglyceride levels were associated with reduced HDL particle diameter and with increased HDL-TG. Using observational and Mendelian randomization analyses, HDL-TG levels were independently associated with atherosclerotic cardiovascular disease risk even after adjusting for multiple confounders and other risk factors. The results emphasize the need for a broader evaluation of lipid parameters that extends beyond traditional measurements and suggest that incorporating metrics like HDL-TG could enhance risk stratification.
期刊介绍：
The Journal of Lipid Research (JLR) publishes original articles and reviews in the broadly defined area of biological lipids. We encourage the submission of manuscripts relating to lipids, including those addressing problems in biochemistry, molecular biology, structural biology, cell biology, genetics, molecular medicine, clinical medicine and metabolism. Major criteria for acceptance of articles are new insights into mechanisms of lipid function and metabolism and/or genes regulating lipid metabolism along with sound primary experimental data. Interpretation of the data is the authors’ responsibility, and speculation should be labeled as such. Manuscripts that provide new ways of purifying, identifying and quantifying lipids are invited for the Methods section of the Journal. JLR encourages contributions from investigators in all countries, but articles must be submitted in clear and concise English.
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