HDL meets triglyceride.

IF 5 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Tugce Akcan, Fredric B Kraemer
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引用次数: 0

Abstract

The study by Liu et al in this issue of the Journal of Lipid Research leverages data from the UK Biobank to explore the impact of HDL-TG on atherosclerotic cardiovascular disease risk. The investigators observed that elevated serum triglyceride levels were associated with reduced HDL particle diameter and with increased HDL-TG. Using observational and Mendelian randomization analyses, HDL-TG levels were independently associated with atherosclerotic cardiovascular disease risk even after adjusting for multiple confounders and other risk factors. The results emphasize the need for a broader evaluation of lipid parameters that extends beyond traditional measurements and suggest that incorporating metrics like HDL-TG could enhance risk stratification.

高密度脂蛋白与甘油三酯相遇。
Liu等人在本期《Journal of脂质研究》上的研究利用了英国生物银行的数据,探讨了HDL-TG对动脉粥样硬化性心血管疾病风险的影响。研究人员观察到血清甘油三酯水平升高与HDL颗粒直径减小和HDL- tg增加有关。通过观察性和孟德尔随机化分析,HDL-TG水平与动脉粥样硬化性心血管疾病风险独立相关,即使在调整了多个混杂因素和其他危险因素后也是如此。结果强调需要对血脂参数进行更广泛的评估,而不仅仅是传统的测量方法,并建议结合像HDL-TG这样的指标可以增强风险分层。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Lipid Research
Journal of Lipid Research 生物-生化与分子生物学
CiteScore
11.10
自引率
4.60%
发文量
146
审稿时长
41 days
期刊介绍: The Journal of Lipid Research (JLR) publishes original articles and reviews in the broadly defined area of biological lipids. We encourage the submission of manuscripts relating to lipids, including those addressing problems in biochemistry, molecular biology, structural biology, cell biology, genetics, molecular medicine, clinical medicine and metabolism. Major criteria for acceptance of articles are new insights into mechanisms of lipid function and metabolism and/or genes regulating lipid metabolism along with sound primary experimental data. Interpretation of the data is the authors’ responsibility, and speculation should be labeled as such. Manuscripts that provide new ways of purifying, identifying and quantifying lipids are invited for the Methods section of the Journal. JLR encourages contributions from investigators in all countries, but articles must be submitted in clear and concise English.
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