Stomach cancer identification based on exhaled breath analysis: a review.

IF 3.7 4区 医学 Q1 BIOCHEMICAL RESEARCH METHODS
E Poornima, E Chandra, Porkodi Rajendran, P B Pankajavalli
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引用次数: 0

Abstract

Early prediction of cancer is crucial for effective treatment decisions. Stomach cancer is one of the worst malignancies in the world because it does not reveal the growth in symptoms. In recent years, non-invasive diagnostic methods, particularly exhaled breath analysis, have attracted interest in detecting stomach cancer. This review discusses invasive and non-invasive diagnostic methods for stomach cancer, with a special emphasis on breath analysis and electronic nose (e-nose) technology. Various analytical methods have been used to analyze volatile organic compounds (VOCs) associated with stomach cancer. Gas chromatography-mass Spectrometry is one of the most widely used techniques. These techniques enable the detection and analysis of VOCs, offering a promising route for early stomach cancer diagnosis. The e-nose system has been introduced as a cost-effective and portable alternative for VOC detection in stomach cancer to overcome the challenges associated with conventional methods. This review discusses the advantages and disadvantages of the e-nose system. This review recommends that e-nose sensors, combined with advanced pattern recognition techniques, be utilized to enable rapid and reliable diagnosis of stomach cancer.

基于呼气分析的胃癌鉴别研究进展。
癌症的早期预测对有效的治疗决策至关重要。胃癌是世界上最严重的恶性肿瘤之一,因为它不会显示出症状的增长。近年来,非侵入性诊断方法,特别是呼气分析,已引起人们对胃癌检测的兴趣。本文综述了胃癌的有创和无创诊断方法,重点介绍了呼吸分析和电子鼻技术。胃癌相关挥发性有机化合物(VOCs)的分析方法多种多样,其中气相色谱-质谱联用(GC-MS)是应用最广泛的分析方法之一。本文综述了非侵入性呼吸方法,以及电子鼻系统的集成。这些技术使VOCs的检测和分析成为可能,为胃癌的早期诊断提供了一条有希望的途径。为了克服与传统方法相关的挑战,电子鼻系统已被引入,作为一种具有成本效益和便携式的VOC检测替代方案。本文综述了电子鼻系统的优缺点。本文建议将电子鼻传感器与先进的模式识别技术相结合,以实现胃癌的快速可靠诊断。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of breath research
Journal of breath research BIOCHEMICAL RESEARCH METHODS-RESPIRATORY SYSTEM
CiteScore
7.60
自引率
21.10%
发文量
49
审稿时长
>12 weeks
期刊介绍: Journal of Breath Research is dedicated to all aspects of scientific breath research. The traditional focus is on analysis of volatile compounds and aerosols in exhaled breath for the investigation of exogenous exposures, metabolism, toxicology, health status and the diagnosis of disease and breath odours. The journal also welcomes other breath-related topics. Typical areas of interest include: Big laboratory instrumentation: describing new state-of-the-art analytical instrumentation capable of performing high-resolution discovery and targeted breath research; exploiting complex technologies drawn from other areas of biochemistry and genetics for breath research. Engineering solutions: developing new breath sampling technologies for condensate and aerosols, for chemical and optical sensors, for extraction and sample preparation methods, for automation and standardization, and for multiplex analyses to preserve the breath matrix and facilitating analytical throughput. Measure exhaled constituents (e.g. CO2, acetone, isoprene) as markers of human presence or mitigate such contaminants in enclosed environments. Human and animal in vivo studies: decoding the ''breath exposome'', implementing exposure and intervention studies, performing cross-sectional and case-control research, assaying immune and inflammatory response, and testing mammalian host response to infections and exogenous exposures to develop information directly applicable to systems biology. Studying inhalation toxicology; inhaled breath as a source of internal dose; resultant blood, breath and urinary biomarkers linked to inhalation pathway. Cellular and molecular level in vitro studies. Clinical, pharmacological and forensic applications. Mathematical, statistical and graphical data interpretation.
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