Exercise modulates brain pulsatility: insights from q-aMRI and MRI-based flow methods.

Abstract

This study investigates intracranial dynamics following the Monro-Kellie doctrine, depicting how brain pulsatility, cerebrospinal fluid (CSF) flow and cerebral blood flow (CBF) interact under resting and exercise conditions. Using quantitative amplified magnetic resonance imaging (q-aMRI) alongside traditional MRI flow metrics, we measured and analysed blood flow, CSF dynamics and brain displacement in a cohort of healthy adults both at rest and during low-intensity handgrip exercise. Exercise was found to reduce pulsatility in CBF while increasing CSF flow and eliminating CSF regurgitation, highlighting a shift towards more sustained forward flow patterns (from cranial to spinal compartments). Displacement analysis using q-aMRI revealed a consistent trend of reduced whole brain motion during exercise, though as the sample of data that met quality control was low (n = 5), this was not a significant result. There was an observable decrease in the motion of third and fourth ventricles, linking ventricular displacement to CSF flow alterations. These findings suggest that exercise may not only affect the rate and directionality of CSF flow but also modulate brain tissue motion, supporting cerebral homeostasis. This study offers insights into how the brain adapts dynamically under varying conditions, with implications for understanding intracranial pressure regulation in humans and diagnostic contexts.