The role of branched-chain amino acids in cardio-oncology: A review

IF 5.2 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Life sciences Pub Date : 2025-04-04 DOI:10.1016/j.lfs.2025.123614

Jiaqi Xu , Yu Wang , Jing Zhang , Jingyi Tang , Zhongyan Zhou

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引用次数: 0

Abstract

Cancer and cardiovascular diseases (CVDs) are global health challenges. In cancer patients, CVD is the second leading cause of death following disease progression. There are few specialized services for cardio-oncology patients worldwide currently. Branched-chain amino acids (BCAAs) are essential amino acids that promote protein synthesis and energy homeostasis. The disruption of BCAAs metabolism facilitates the development of cancer and CVDs while the benefit of BCAA supplement is full of controversy. In this review, we summarized BCAA-related studies in cardiometabolism, cancer and chemotherapy-induced cardiotoxicity, and provided our perspectives on the roles of BCAAs in cardio-oncology. We find that supplementation of BCAAs presents protective effects in cardiometabolic diseases, while the influence on cancer is intricate and varies across different types of cancers. Large-scale clinical studies are needed to understand the long-term effects of BCAA intake and its impact on different stages of the disease. BCAAs have potential to mitigate chemotherapy-induced cardiotoxicity. Continued research is still essential to understand the precise mechanisms, determine optimal dosage and timing, and assess the effectiveness of BCAA supplement in cardio-oncology, in particular clinical research.

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支链氨基酸在心脏肿瘤学中的作用综述。

癌症和心血管疾病（CVDs）是全球性的健康挑战。在癌症患者中，心血管疾病是继疾病进展之后的第二大死亡原因。目前，全球针对心血管肿瘤患者的专业服务很少。支链氨基酸（BCAAs）是人体必需的氨基酸，能促进蛋白质合成和能量平衡。支链氨基酸代谢紊乱会导致癌症和心血管疾病的发生，而补充支链氨基酸的益处却充满争议。在这篇综述中，我们总结了 BCAAs 在心脏代谢、癌症和化疗诱导的心脏毒性方面的相关研究，并对 BCAAs 在心脏肿瘤学研究中的作用提出了自己的观点。我们发现，补充 BCAAs 对心脏代谢疾病有保护作用，而对癌症的影响则错综复杂，且因癌症类型而异。需要进行大规模临床研究，以了解摄入 BCAA 的长期效果及其对不同疾病阶段的影响。BCAAs 有可能减轻化疗引起的心脏毒性，如多柔比星（DOX）和 5-氟尿嘧啶（5-FU）。要了解 BCAAs 补充剂的确切机制、确定最佳使用方法并评估其有效性，仍需继续开展研究。

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来源期刊

Life sciences 医学-药学

CiteScore

12.20

自引率

1.60%

发文量

841

审稿时长

6 months

期刊介绍： Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. The journal emphasizes the understanding of mechanism that is relevant to all aspects of human disease and translation to patients. All articles are rigorously reviewed. The Journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms. Articles that merely report observations are rarely accepted. Recommendations from the Declaration of Helsinki or NIH guidelines for care and use of laboratory animals must be adhered to. Articles should be written at a level accessible to readers who are non-specialists in the topic of the article themselves, but who are interested in the research. The Journal welcomes reviews on topics of wide interest to investigators in the life sciences. We particularly encourage submission of brief, focused reviews containing high-quality artwork and require the use of mechanistic summary diagrams.