PKM2-mediated metabolic reprogramming of microglia in neuroinflammation.

IF 6.1 2区生物学 Q1 CELL BIOLOGY

Cell Death Discovery Pub Date : 2025-04-06 DOI:10.1038/s41420-025-02453-5

Qi Zhang, Sha-Sha Wang, Zhao Zhang, Shi-Feng Chu

引用次数: 0

Abstract

Microglia, the resident immune cells of the central nervous system, undergo metabolic reprogramming during neuroinflammation, playing a crucial role in the pathogenesis of neurological disorders such as Parkinson's disease. This review focuses on Pyruvate Kinase M2 (PKM2), a key glycolytic enzyme, and its impact on microglial metabolic reprogramming and subsequent neuroinflammation. We explore the regulatory mechanisms governing PKM2 activity, its influence on microglial activation and immune responses, and its contribution to the progression of various neurological diseases. Finally, we highlight the therapeutic potential of targeting PKM2 as a novel strategy for treating neuroinflammation-driven neurological disorders. This review provides insights into the molecular mechanisms of PKM2 in neuroinflammation, aiming to inform the development of future therapeutic interventions.

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小胶质细胞是中枢神经系统的常驻免疫细胞，在神经炎症过程中会发生代谢重编程，在帕金森病等神经系统疾病的发病机制中起着至关重要的作用。本综述重点研究丙酮酸激酶 M2 (PKM2)（一种关键的糖酵解酶）及其对小胶质细胞代谢重编程和随后的神经炎症的影响。我们探讨了 PKM2 活性的调控机制、它对小胶质细胞活化和免疫反应的影响，以及它对各种神经系统疾病进展的贡献。最后，我们强调了靶向 PKM2 作为治疗神经炎症驱动的神经系统疾病的新策略的治疗潜力。本综述深入探讨了 PKM2 在神经炎症中的分子机制，旨在为未来治疗干预措施的开发提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Death Discovery Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

8.30

自引率

1.40%

发文量

468

审稿时长

9 weeks

期刊介绍： Cell Death Discovery is a multidisciplinary, international, online-only, open access journal, dedicated to publishing research at the intersection of medicine with biochemistry, pharmacology, immunology, cell biology and cell death, provided it is scientifically sound. The unrestricted access to research findings in Cell Death Discovery will foster a dynamic and highly productive dialogue between basic scientists and clinicians, as well as researchers in industry with a focus on cancer, neurobiology and inflammation research. As an official journal of the Cell Death Differentiation Association (ADMC), Cell Death Discovery will build upon the success of Cell Death & Differentiation and Cell Death & Disease in publishing important peer-reviewed original research, timely reviews and editorial commentary. Cell Death Discovery is committed to increasing the reproducibility of research. To this end, in conjunction with its sister journals Cell Death & Differentiation and Cell Death & Disease, Cell Death Discovery provides a unique forum for scientists as well as clinicians and members of the pharmaceutical and biotechnical industry. It is committed to the rapid publication of high quality original papers that relate to these subjects, together with topical, usually solicited, reviews, editorial correspondence and occasional commentaries on controversial and scientifically informative issues.