Risks of respiratory and circulatory system diseases induced by exposure to PM2.5 in high humidity and low solar radiation environments: disease types, genes, and functions.
Xiaomeng Li, Liru Zhang, Zhengliang Zhang, Xuan Li, Jingli Qian, Jiawei Zhou, Hanxiong Che, Yan Han, Xin Qi, Fumo Yang, Yu Huang, Chao Peng, Yang Chen, Yan Xing, Shumin Zhang
{"title":"Risks of respiratory and circulatory system diseases induced by exposure to PM<sub>2.5</sub> in high humidity and low solar radiation environments: disease types, genes, and functions.","authors":"Xiaomeng Li, Liru Zhang, Zhengliang Zhang, Xuan Li, Jingli Qian, Jiawei Zhou, Hanxiong Che, Yan Han, Xin Qi, Fumo Yang, Yu Huang, Chao Peng, Yang Chen, Yan Xing, Shumin Zhang","doi":"10.1007/s10653-025-02465-1","DOIUrl":null,"url":null,"abstract":"<p><p>Epidemiological investigation has found that PM<sub>2.5</sub> from high humidity and low solar radiation environments (HHLR-PM<sub>2.5</sub>) induces the highest premature mortality rates from respiratory and circulatory diseases in China. However, the disease types and pathogenic mechanisms of the respiratory and circulatory diseases induced by HHLR-PM<sub>2.5</sub> have not been completely revealed. In this study, we explore the risks of commonly existing diseases induced by HHLR-PM<sub>2.5</sub> in the respiratory and circulatory systems. For neoplasms, HHLR-PM<sub>2.5</sub> significantly induces malignant mesothelioma and arteriovenous hemangioma, the former through the CDKN1A and KIT genes, and the latter through IL6, blood vessel morphogenesis, and transforming growth factor beta binding. Patent ductus arteriosus-persisting type and chronic thromboembolic pulmonary hypertension are the most prominent cardiopulmonary diseases caused by HHLR-PM<sub>2.5</sub>, with the key molecular target being ACTA2 for the former and CDH5 for the latter. For congenital, hereditary, and neonatal diseases and abnormalities, HHLR-PM<sub>2.5</sub> obviously contributes to bronchopulmonary dysplasia and congenital arteriovenous malformation, the former by targeting HMOX1, response to glucocorticoid, and heparin binding, and the latter by targeting IL6, blood vessel morphogenesis, and transforming growth factor beta binding. This study helps to clarify the risks of HHLR-PM<sub>2.5</sub> to the respiratory and circulatory systems, supporting and supplementing epidemiology data.</p>","PeriodicalId":11759,"journal":{"name":"Environmental Geochemistry and Health","volume":"47 5","pages":"155"},"PeriodicalIF":3.2000,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Environmental Geochemistry and Health","FirstCategoryId":"93","ListUrlMain":"https://doi.org/10.1007/s10653-025-02465-1","RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENGINEERING, ENVIRONMENTAL","Score":null,"Total":0}
引用次数: 0
Abstract
Epidemiological investigation has found that PM2.5 from high humidity and low solar radiation environments (HHLR-PM2.5) induces the highest premature mortality rates from respiratory and circulatory diseases in China. However, the disease types and pathogenic mechanisms of the respiratory and circulatory diseases induced by HHLR-PM2.5 have not been completely revealed. In this study, we explore the risks of commonly existing diseases induced by HHLR-PM2.5 in the respiratory and circulatory systems. For neoplasms, HHLR-PM2.5 significantly induces malignant mesothelioma and arteriovenous hemangioma, the former through the CDKN1A and KIT genes, and the latter through IL6, blood vessel morphogenesis, and transforming growth factor beta binding. Patent ductus arteriosus-persisting type and chronic thromboembolic pulmonary hypertension are the most prominent cardiopulmonary diseases caused by HHLR-PM2.5, with the key molecular target being ACTA2 for the former and CDH5 for the latter. For congenital, hereditary, and neonatal diseases and abnormalities, HHLR-PM2.5 obviously contributes to bronchopulmonary dysplasia and congenital arteriovenous malformation, the former by targeting HMOX1, response to glucocorticoid, and heparin binding, and the latter by targeting IL6, blood vessel morphogenesis, and transforming growth factor beta binding. This study helps to clarify the risks of HHLR-PM2.5 to the respiratory and circulatory systems, supporting and supplementing epidemiology data.
期刊介绍：
Environmental Geochemistry and Health publishes original research papers and review papers across the broad field of environmental geochemistry. Environmental geochemistry and health establishes and explains links between the natural or disturbed chemical composition of the earth’s surface and the health of plants, animals and people.
Beneficial elements regulate or promote enzymatic and hormonal activity whereas other elements may be toxic. Bedrock geochemistry controls the composition of soil and hence that of water and vegetation. Environmental issues, such as pollution, arising from the extraction and use of mineral resources, are discussed. The effects of contaminants introduced into the earth’s geochemical systems are examined. Geochemical surveys of soil, water and plants show how major and trace elements are distributed geographically. Associated epidemiological studies reveal the possibility of causal links between the natural or disturbed geochemical environment and disease. Experimental research illuminates the nature or consequences of natural or disturbed geochemical processes.
The journal particularly welcomes novel research linking environmental geochemistry and health issues on such topics as: heavy metals (including mercury), persistent organic pollutants (POPs), and mixed chemicals emitted through human activities, such as uncontrolled recycling of electronic-waste; waste recycling; surface-atmospheric interaction processes (natural and anthropogenic emissions, vertical transport, deposition, and physical-chemical interaction) of gases and aerosols; phytoremediation/restoration of contaminated sites; food contamination and safety; environmental effects of medicines; effects and toxicity of mixed pollutants; speciation of heavy metals/metalloids; effects of mining; disturbed geochemistry from human behavior, natural or man-made hazards; particle and nanoparticle toxicology; risk and the vulnerability of populations, etc.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
