The role of cancer-associated fibroblasts in the tumour microenvironment of urinary system

IF 7.9 1区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Clinical and Translational Medicine Pub Date : 2025-04-07 DOI:10.1002/ctm2.70299

Ri Hong, Puguang Yu, Xiaoli Zhang, Peng Su, Hongyuan Liang, Dan Dong, Xuesong Wang, Kefeng Wang

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Abstract

Urological tumours are a type of neoplasms that significantly jeopardise human life and wellbeing. Cancer-associated fibroblasts (CAFs), serving as the primary component of the stromal cellular milieu, form a diverse cellular cohort that exerts substantial influence on tumourigenesis and tumour progression. In this review, we summarised the literatures regarding the functions of CAFs in the urinary tumour microenvironment (TME). We primarily examined the multifaceted activities of CAFs in the TME of urological system tumours, including inhibiting tumour immunity, remodelling the extracellular matrix, promoting tumour growth, metastasis, drug resistance and their clinical applications. We also discussed potential future directions for leveraging artificial intelligence in CAFs research.

Key points

The interaction of CAFs with various cell secretory factors in the TME of urological tumors.
The application of CAFs in diagnosis, treatment and prognosis of urological tumors.

Abstract Image

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癌症相关成纤维细胞在泌尿系统肿瘤微环境中的作用

泌尿系统肿瘤是一种严重危害人类生命和健康的肿瘤。癌症相关成纤维细胞（CAFs）作为基质细胞环境的主要组成部分，形成了一个多样化的细胞队列，对肿瘤的发生和肿瘤的进展产生重大影响。本文就CAFs在泌尿肿瘤微环境（TME）中的作用进行综述。我们主要研究了CAFs在泌尿系统肿瘤TME中的多方面活性，包括抑制肿瘤免疫、重塑细胞外基质、促进肿瘤生长、转移、耐药及其临床应用。我们还讨论了在人工智能研究中利用人工智能的潜在未来方向。在泌尿系统肿瘤TME中，CAFs与多种细胞分泌因子的相互作用。CAFs在泌尿系统肿瘤诊断、治疗及预后中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Translational Medicine Multiple-

CiteScore

15.90

自引率

1.90%

发文量

450

审稿时长

4 weeks

期刊介绍： Clinical and Translational Medicine (CTM) is an international, peer-reviewed, open-access journal dedicated to accelerating the translation of preclinical research into clinical applications and fostering communication between basic and clinical scientists. It highlights the clinical potential and application of various fields including biotechnologies, biomaterials, bioengineering, biomarkers, molecular medicine, omics science, bioinformatics, immunology, molecular imaging, drug discovery, regulation, and health policy. With a focus on the bench-to-bedside approach, CTM prioritizes studies and clinical observations that generate hypotheses relevant to patients and diseases, guiding investigations in cellular and molecular medicine. The journal encourages submissions from clinicians, researchers, policymakers, and industry professionals.