{"title":"Immunology laboratory methods","authors":"Sarah E Linstead, Joanne Morris, Rachel D Wheeler","doi":"10.1016/j.mpmed.2025.02.003","DOIUrl":null,"url":null,"abstract":"<div><div>Immunoglobulins, or antibodies, are soluble glycoproteins that are produced by cells of the B cell lineage and can be detected in measurable amounts in the blood. Assessing the amount, isotype and clonality of immunoglobulins is useful for the diagnosis, prognosis and monitoring of haematological malignancies relating to B cells, such as myeloma and lymphoma. This chapter provides an overview of the laboratory tests that specifically measure the amount and clonality of immunoglobulins, and discusses how to interpret the results, including possible confounding factors.</div></div>","PeriodicalId":74157,"journal":{"name":"Medicine (Abingdon, England : UK ed.)","volume":"53 4","pages":"Pages 191-194"},"PeriodicalIF":0.0000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicine (Abingdon, England : UK ed.)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1357303925000271","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Immunoglobulins, or antibodies, are soluble glycoproteins that are produced by cells of the B cell lineage and can be detected in measurable amounts in the blood. Assessing the amount, isotype and clonality of immunoglobulins is useful for the diagnosis, prognosis and monitoring of haematological malignancies relating to B cells, such as myeloma and lymphoma. This chapter provides an overview of the laboratory tests that specifically measure the amount and clonality of immunoglobulins, and discusses how to interpret the results, including possible confounding factors.
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