Clinical implementation of patient-specific quality assurance for synthetic computed tomography

Abstract

Background and purpose

In a magnetic resonance (MR) only planning workflow, MR image is the sole dataset acquired. In order to calculate the dose deposition, a synthetic CT (sCT) is generated to substitute the planning computed tomography (CT). This study aimed to establish acceptance criteria for the clinical implementation of patient-specific quality assurance (PSQA) for sCT.

Materials and methods

A retrospective study was conducted on 60. 30 patients underwent a CT scan in treatment position and an MR in diagnostic position. 30 patients had both CT and MR images acquired in treatment position. For the latter group, a sCT for dose calculation was generated and compared against three PSQA methods: recalculation on (A) water override of the body, (B) tissue classes with bulk density overrides and (C) planning CT. The relative dose differences (ΔD [%]) between the sCT and the PSQA methos were evaluated.

Results

ΔD for PTV Dmean for method (A) were within 3% for pelvis and 4% for brain cohorts, with standard deviations below 1%. Methods (B) and (C) remained within 2% and 1%, respectively, with deviations up to 1%.

Conclusion

The present study proposes a robust PSQA method for MR-only planning. Method (A) is a valuable tool for identifying potential large outliers for Dmean deviations (> 5 %) and it is proposed as the routine PSQA. Method (B) can be used for pelvis cases to improve detection to the 2 % level if method (A) fails. If both (A) and (B) fail, method (C) can be used as a fall-back.