Knowledge-Based RapidPlan Volumetric Modulated Arc Therapy Model in Nasopharyngeal Carcinoma

IF 2.2 Q3 ONCOLOGY

Advances in Radiation Oncology Pub Date : 2025-01-13 DOI:10.1016/j.adro.2025.101716

Szu-Huai Lu MS , Chun-Wei Wang MD, PhD , Hsiang-Kuang Liang MD, PhD , Chih-Kai Chang MS , Hao-Ting Lan MS , Shih-Fan Lai MD , Bing-Shen Huang MD, PhD , Wan- Yu Chen MD, PhD

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引用次数: 0

Abstract

Purpose

RapidPlan^TM (RP) Eclipse^@, a commercial knowledge-based planning software, predicts radiation doses, enhancing treatment planning efficiency and quality. This study developed a nasopharyngeal carcinoma (NPC) volumetric modulated arc therapy RP model and assessed its quality and efficiency against manual plans.

Methods and Materials

The existing plans for 160 patients with NPC constituted the RP model training cohort. An additional 33 patients formed a testing cohort to compare RP and manual plans based on dose-volume histograms, isodose curves, physician plan scores, and selection.

Results

The RP plan could be completed within 1 hour. RP plans demonstrated superior conformity compared with manual plans in planning target volume 70. RP plans outperformed manual plans in reducing organs-at-risks (OARs) doses. For advanced T3/4 tumors, chiasma and optic nerve doses remained similar to manual plans. RP plans had higher physician-rated scores in dose-volume histograms of targets, OARs, isodose curves, and holistic scores. Clinical plan acceptance rates of RP plans reached 100%. Physicians chose RP plans over manual plans for 31, 30, and 28 patients for doctors A, B, and C, mainly because of superior OAR sparing and higher conformity.

Conclusions

The RP plan efficiently generates high-quality NPC volumetric modulated arc therapy plans. Further applications of RP Eclipse in single-institutional clinical flows and multi-institutional collaborations or clinical trials are warranted.

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基于知识的RapidPlan体积调节弧线治疗模型在鼻咽癌中的应用

apidplantm (RP) Eclipse@是一款基于知识的商业计划软件，用于预测辐射剂量，提高治疗计划的效率和质量。本研究建立鼻咽癌（NPC）体积调节弧线治疗RP模型，并对比人工方案评估其质量和效率。方法与材料现有计划的160例鼻咽癌患者组成RP模型训练队列。另外33名患者组成了一个测试队列，比较RP和基于剂量-体积直方图、等剂量曲线、医生计划评分和选择的手动计划。结果RP方案可在1小时内完成。在规划目标卷70中，RP计划比手工计划表现出更好的一致性。RP计划在减少器官危险（OARs）剂量方面优于手动计划。对于晚期T3/4肿瘤，交叉和视神经剂量与手工计划相似。RP方案在靶的剂量-体积直方图、OARs、等剂量曲线和整体评分方面具有较高的医生评分。RP方案临床方案合格率达100%。医生A、B和C的31例、30例和28例患者选择RP方案而不是手工方案，主要是因为更好的OAR保留和更高的一致性。结论RP方案可有效生成高质量的鼻咽癌体积调节弧治疗方案。RP Eclipse在单机构临床流程和多机构合作或临床试验中的进一步应用是有保证的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in Radiation Oncology Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

4.60

自引率

4.30%

发文量

208

审稿时长

98 days

期刊介绍： The purpose of Advances is to provide information for clinicians who use radiation therapy by publishing: Clinical trial reports and reanalyses. Basic science original reports. Manuscripts examining health services research, comparative and cost effectiveness research, and systematic reviews. Case reports documenting unusual problems and solutions. High quality multi and single institutional series, as well as other novel retrospective hypothesis generating series. Timely critical reviews on important topics in radiation oncology, such as side effects. Articles reporting the natural history of disease and patterns of failure, particularly as they relate to treatment volume delineation. Articles on safety and quality in radiation therapy. Essays on clinical experience. Articles on practice transformation in radiation oncology, in particular: Aspects of health policy that may impact the future practice of radiation oncology. How information technology, such as data analytics and systems innovations, will change radiation oncology practice. Articles on imaging as they relate to radiation therapy treatment.