Clinicopathological study of 34 cases of clear cell adenocarcinoma of the urinary tract and diagnostic value of SOX 17 in its differential diagnosis

IF 2.7 2区医学 Q2 PATHOLOGY

Human pathology Pub Date : 2025-03-01 DOI:10.1016/j.humpath.2025.105767

Lan Zheng , Georges Tabet , Charles C. Guo , Yasmeen Oamar Rizvi , Maria Gabriela Raso , Jinsong Liu , Qingqing Ding , Ezra Baraban , Jianping Zhao

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Abstract

Clear cell adenocarcinoma (CCA) of the urinary tract is a rare tumor with a female predominance. The morphological features and immunoprofile of urinary CCA, CCA of the gynecologic tract (Gyn CCA), and nephrogenic adenoma (NA) can show extensive overlap, and the differential diagnosis can be challenging especially in small biopsies. SOX17 is a newly identified sensitive and specific immunomarker for endometrial and ovarian carcinomas including Gyn CCA. However, its expression in urinary CCA and NA has not been studied. We studied clinical and pathological features of 34 cases of urinary CCA, the largest cohort in the literature to date. We analyzed the expression pattern of SOX17 in a cohort of 34 urinary CCA, 24 Gyn CCA, and 18 NA. Interestingly, 29 % (10/34) of urinary CCA showed high SOX17 expression, while all the NA cases (18/18) showed negative-low expression. In female, 51 % of urinary CCA cases (15/29) show negative-low expression of SOX17, whereas all Gyn CCA (24/24) showed high SOX17 positivity. Our study showed a unique expression pattern of SOX17 in urinary CCA and NA. These results suggest that SOX17 is a useful marker in distinguishing CCA from NA or urinary CCA from Gyn CCA. Moreover, our study suggests different pathogenic pathways for the histogenesis of urinary CCA.

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来源期刊

Human pathology 医学-病理学

CiteScore

5.30

自引率

6.10%

发文量

206

审稿时长

21 days

期刊介绍： Human Pathology is designed to bring information of clinicopathologic significance to human disease to the laboratory and clinical physician. It presents information drawn from morphologic and clinical laboratory studies with direct relevance to the understanding of human diseases. Papers published concern morphologic and clinicopathologic observations, reviews of diseases, analyses of problems in pathology, significant collections of case material and advances in concepts or techniques of value in the analysis and diagnosis of disease. Theoretical and experimental pathology and molecular biology pertinent to human disease are included. This critical journal is well illustrated with exceptional reproductions of photomicrographs and microscopic anatomy.