Assessment of the association between constipation and atherosclerosis in cardiovascular and cerebrovascular diseases: a systematic review and meta-analysis.
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Abstract
This study examines the association between constipation and cardiovascular and cerebrovascular diseases linked to atherosclerosis. A systematic review of studies published from 2000 to August 2024 was performed using PubMed, Web of Science, Cochrane, and EMBASE databases. Twelve studies, encompassing 5,772,682 adults from six countries, met inclusion criteria and were quality-assessed via the NOS and AHRQ scales. Meta-analysis results indicated a significant association, with an odds ratio of 1.18 (95% CI: 1.08-1.30), suggesting that constipation may elevate the risk of atherosclerosis-related cardiovascular and cerebrovascular conditions.
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