Assessment of the association between constipation and atherosclerosis in cardiovascular and cerebrovascular diseases: a systematic review and meta-analysis.

The American journal of the medical sciences Pub Date : 2025-04-03 DOI:10.1016/j.amjms.2025.04.001

Xiang Wang, Kaiwen Zheng, Quan Zhang

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Abstract

Introduction: Cardiovascular and cerebrovascular diseases remain leading causes of morbidity and mortality worldwide, with atherosclerosis as a key underlying mechanism.

Methods: A systematic review was conducted of studies published between 2000 and August 2024, sourced from PubMed, Web of Science, Cochrane, and EMBASE databases. Twelve studies, involving 5,772,682 adults across six countries, met predefined inclusion criteria. Study quality was assessed using the Newcastle-Ottawa Scale (NOS) and the Agency for Healthcare Research and Quality (AHRQ) scale. A meta-analysis was performed to quantify the association.

Results: The meta-analysis revealed a statistically significant association between constipation and atherosclerosis-related cardiovascular and cerebrovascular diseases, with a pooled odds ratio of 1.18 (95 % CI: 1.08-1.30). This finding indicates that individuals with constipation may face an elevated risk of these conditions.

Conclusions: These findings suggest that constipation could serve as a potential risk factor or marker warranting further investigation in clinical and mechanistic studies.

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评价心脑血管疾病患者便秘与动脉粥样硬化之间的关系：一项系统综述和荟萃分析

本研究探讨了便秘与与动脉粥样硬化相关的心脑血管疾病之间的关系。使用PubMed、Web of Science、Cochrane和EMBASE数据库对2000年至2024年8月发表的研究进行系统回顾。12项研究，包括来自6个国家的5,772,682名成年人，符合纳入标准，并通过NOS和AHRQ量表进行了质量评估。荟萃分析结果显示两者有显著相关性，比值比为1.18 (95% CI: 1.08-1.30)，提示便秘可能会增加动脉粥样硬化相关心脑血管疾病的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The American journal of the medical sciences

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