Vitamin D receptor: a possible biomarker for sporadic parathyroid adenoma?

IF 2.4 3区医学 Q2 SURGERY

Updates in Surgery Pub Date : 2025-04-05 DOI:10.1007/s13304-025-02182-5

Angeliki Chorti, Angeliki Cheva, Kassiani Boulogeorgou, Anthoula Chatzikyriakidou, Charoula Achilla, Despoina Tsalkatidou, Despoina Krokou, Sohail Bakkar, Papavramidis Theodossis

引用次数: 0

Abstract

Parathyroid adenoma is the main cause of primary hyperparathyroidism. The genetic basis of the disease is still unclear. Vitamin D receptor (VDR) is involved in parathormone regulation. The aim of this study is to evaluate Vitamin D receptor expression in sporadic parathyroid adenoma. Fifty-one patients with parathyroid adenoma and 51 healthy volunteers were enrolled in the study and genetic and immunohistochemical studies were conducted. VDR polymorphism TaqI was correlated with parathyroid adenoma development, while VDR stained positive in immunohistochemical study. Our study suggests VDR as a major contributor to sporadic parathyroid adenoma formation in Greek population.

查看原文本刊更多论文

维生素D受体：散发性甲状旁腺瘤可能的生物标志物？

甲状旁腺腺瘤是原发性甲状旁腺功能亢进症的主要病因。该病的遗传基础尚不清楚。维生素D受体（VDR）参与副激素的调节。本研究旨在评估散发性甲状旁腺腺瘤中维生素D受体的表达。研究共纳入了51名甲状旁腺腺瘤患者和51名健康志愿者，并进行了遗传学和免疫组化研究。VDR多态性TaqI与甲状旁腺腺瘤的发生有关，而VDR在免疫组化研究中呈阳性。我们的研究表明，VDR是希腊人群中形成散发性甲状旁腺腺瘤的主要因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Updates in Surgery Medicine-Surgery

CiteScore

4.50

自引率

7.70%

发文量

208

期刊介绍： Updates in Surgery (UPIS) has been founded in 2010 as the official journal of the Italian Society of Surgery. It’s an international, English-language, peer-reviewed journal dedicated to the surgical sciences. Its main goal is to offer a valuable update on the most recent developments of those surgical techniques that are rapidly evolving, forcing the community of surgeons to a rigorous debate and a continuous refinement of standards of care. In this respect position papers on the mostly debated surgical approaches and accreditation criteria have been published and are welcome for the future. Beside its focus on general surgery, the journal draws particular attention to cutting edge topics and emerging surgical fields that are publishing in monothematic issues guest edited by well-known experts. Updates in Surgery has been considering various types of papers: editorials, comprehensive reviews, original studies and technical notes related to specific surgical procedures and techniques on liver, colorectal, gastric, pancreatic, robotic and bariatric surgery.