A serial mediation model of chronic multimorbidity and frailty in older adults: the role of pain and depressive symptoms.

Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society Pub Date : 2025-05-01 DOI:10.1111/psyg.70030

Ting Rong, Li Kang, Yi Zhang, Lanxin Yin, Yuexia Gao, Jianlin Gao

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Abstract

Background: Previous studies have shown that chronic multimorbidity is associated with frailty in older adults. However, the mechanisms of this association are unclear. This study aimed to determine the mediating role of pain and depressive symptoms in the relationship between chronic multimorbidity and frailty.

Methods: We examined the relationship between chronic multimorbidity, pain, depressive symptoms, and frailty in a cross-sectional survey of 501 older adults (48.5% male, median age = 74 years).

Results: There was a positive correlation between chronic multimorbidity and frailty in older adults. In addition, pain and depressive symptoms mediated the relationship between chronic multimorbidity and frailty both independently and serially. The total indirect effect of the three mediation paths was 36%.

Conclusion: Active treatment of the primary conditions of older adults, supplemented by attention given to physical and mental health issues such as pain and depressive symptoms, could prevent the development of frailty in older adults.

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老年人慢性多病和虚弱的一系列中介模型：疼痛和抑郁症状的作用。

背景：先前的研究表明，慢性多病与老年人虚弱有关。然而，这种关联的机制尚不清楚。本研究旨在确定疼痛和抑郁症状在慢性多病和虚弱之间的中介作用。方法：我们对501名老年人（48.5%为男性，中位年龄为74岁）进行横断面调查，研究慢性多病、疼痛、抑郁症状和虚弱之间的关系。结果：老年人慢性多病与身体虚弱呈正相关。此外，疼痛和抑郁症状在慢性多病和虚弱之间独立或串联起中介作用。三种中介途径的间接效应合计为36%。结论：积极治疗老年人的原发性疾病，辅以对疼痛和抑郁症状等身心健康问题的关注，可以预防老年人虚弱的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society

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