Anti-Inflammatory Diet Index and risk of renal cell carcinoma.

IF 6.4 1区医学 Q1 ONCOLOGY

British Journal of Cancer Pub Date : 2025-04-05 DOI:10.1038/s41416-025-03000-w

Tahir Taj, Pernilla Sundqvist, Alicja Wolk, Katja Fall, Henrik Ugge

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Abstract

Introduction: A diet rich in fruits, vegetables, coffee, and tea, limited red meat, and moderate alcohol intake may reduce the risk of renal cell carcinoma (RCC). The anti-inflammatory potential of diet has been proposed as a mechanism influencing cancer risk. This study assessed the association between an anti-inflammatory diet and RCC risk.

Methodology: Data from two Swedish cohorts, the Swedish-Mammography-Cohort and the Cohort-of-Swedish-Men, were analysed. Dietary habits were assessed using a 96-item food frequency questionnaire. The Anti-Inflammatory Diet Index (AIDI), composed of 16 food groups (11 anti-inflammatory and 5 pro-inflammatory), was used to score dietary patterns. RCC cases were identified from the Swedish Cancer Register using ICD-10 codes, and Cox proportional hazards models were used to estimate hazard ratios based on AIDI quartiles.

Results: Among 71,421 participants, 431 RCC cases were identified during a 19.7-year follow-up. Higher AIDI scores were associated with a lower RCC risk (HR for Q4 vs. Q1: 0.68, CI: 0.52-0.89). In sex-stratified analyses (p-for heterogeneity = 0.006), the association was stronger in among women (HR: 0.47, CI: 0.30-0.75) but less clear in among men (HR: 0.83, CI: 0.63-1.24).

Conclusion: These data suggest that adherence to an anti-inflammatory diet may confer a reduced risk for RCC, especially among women.

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抗炎饮食指数与肾细胞癌的风险。

饮食中多吃水果、蔬菜、咖啡和茶，少吃红肉，适量饮酒可以降低患肾细胞癌的风险。饮食的抗炎潜力被认为是影响癌症风险的一种机制。这项研究评估了抗炎饮食与肾癌风险之间的关系。方法：分析了两个瑞典队列的数据，瑞典乳房x线摄影队列和瑞典男性队列。饮食习惯通过96项食物频率问卷进行评估。采用抗炎饮食指数（AIDI）对饮食模式进行评分，该指数由16组食物（11组抗炎食物和5组促炎食物）组成。使用ICD-10代码从瑞典癌症登记册中确定RCC病例，并使用Cox比例风险模型来估计基于AIDI四分位数的风险比。结果：在71421名参与者中，在19.7年的随访中发现了431例RCC病例。较高的AIDI评分与较低的RCC风险相关（第四季度相对于第一季度的HR: 0.68, CI: 0.52-0.89）。在性别分层分析中（p-异质性= 0.006），女性的相关性更强（HR: 0.47, CI: 0.30-0.75），但男性的相关性不太明显（HR: 0.83, CI: 0.63-1.24）。结论：这些数据表明，坚持抗炎饮食可能会降低患RCC的风险，尤其是在女性中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

British Journal of Cancer 医学-肿瘤学

CiteScore

15.10

自引率

1.10%

发文量

383

审稿时长

6 months

期刊介绍： The British Journal of Cancer is one of the most-cited general cancer journals, publishing significant advances in translational and clinical cancer research.It also publishes high-quality reviews and thought-provoking comment on all aspects of cancer prevention,diagnosis and treatment.