Recurrence of hypoglycaemia and associated factors among neonates admitted with perinatal asphyxia in Northwest Ethiopia: multicentre, retrospective follow-up study with negative binomial regression.
{"title":"Recurrence of hypoglycaemia and associated factors among neonates admitted with perinatal asphyxia in Northwest Ethiopia: multicentre, retrospective follow-up study with negative binomial regression.","authors":"Gezahagn Demsu Gedefaw, Temesgen Brilie Asmare, Asnake Tadesse Abate, Wubet Tazeb Wondie, Mulugeta Endalamaw Ayenew, Astewil Moges Bazezew, Tsehayu Melak Siyoum, Degalem Tilahun Worku, Yaregal Semanew Endeshaw","doi":"10.1136/bmjopen-2024-096158","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To estimate the recurrence of hypoglycaemia and the associated factors in neonates with birth asphyxia admitted to the neonatal intensive care unit in Northwest Amhara region's comprehensive specialised hospitals, Northwest Ethiopia, in 2024.</p><p><strong>Design: </strong>A multicentre, institution-based, retrospective follow-up study.</p><p><strong>Setting: </strong>Tertiary hospitals in Northwest Amhara Regional State, Northwest Ethiopia, from 1 July 2020 to 30 July 2024.</p><p><strong>Participants: </strong>A total of 761 neonates with perinatal asphyxia were admitted to the neonatal intensive care unit of selected public hospitals in Northwest Amhara from July 2020 to July 2024.</p><p><strong>Outcome measure: </strong>The primary outcome measure of this study was recurrence of hypoglycaemia. Furthermore, the factors associated with recurrence of hypoglycaemia in newborns with perinatal asphyxia were noted.</p><p><strong>Results: </strong>The average number of hypoglycaemia cases among neonates with birth asphyxia was 2.05 (95% CI 1.939, 2.163) over the 28-day follow-up period. Meningitis (adjusted incidence rate ratio (AIRR)=1.16; 95% CI 1.04, 1.30), feeding in less than 72 hours (AIRR=1.17; 95% CI 1.05, 1.31), stage 3 hypoxic-ischaemic injury (AIRR=1.20; 95% CI 1.04, 1.39), length of hospital stay (AIRR=1.01; 95% CI 1.01, 1.03) and macrosomia (AIRR=1.39; 95% CI 1.19, 1.63) were significant factors associated with recurrence of hypoglycaemia.</p><p><strong>Conclusions and recommendations: </strong>The current study indicated that the mean recurrence of hypoglycaemia in newborns experiencing perinatal asphyxia was considerably higher. Presence of neonatal meningitis, delayed initiation of feeding 72 hours after birth, stage 3 hypoxic-ischaemic injury, length of hospital stay and macrosomia were the key factors associated with recurrence of hypoglycaemia.</p>","PeriodicalId":9158,"journal":{"name":"BMJ Open","volume":"15 4","pages":"e096158"},"PeriodicalIF":2.4000,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973778/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMJ Open","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1136/bmjopen-2024-096158","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: To estimate the recurrence of hypoglycaemia and the associated factors in neonates with birth asphyxia admitted to the neonatal intensive care unit in Northwest Amhara region's comprehensive specialised hospitals, Northwest Ethiopia, in 2024.
Design: A multicentre, institution-based, retrospective follow-up study.
Setting: Tertiary hospitals in Northwest Amhara Regional State, Northwest Ethiopia, from 1 July 2020 to 30 July 2024.
Participants: A total of 761 neonates with perinatal asphyxia were admitted to the neonatal intensive care unit of selected public hospitals in Northwest Amhara from July 2020 to July 2024.
Outcome measure: The primary outcome measure of this study was recurrence of hypoglycaemia. Furthermore, the factors associated with recurrence of hypoglycaemia in newborns with perinatal asphyxia were noted.
Results: The average number of hypoglycaemia cases among neonates with birth asphyxia was 2.05 (95% CI 1.939, 2.163) over the 28-day follow-up period. Meningitis (adjusted incidence rate ratio (AIRR)=1.16; 95% CI 1.04, 1.30), feeding in less than 72 hours (AIRR=1.17; 95% CI 1.05, 1.31), stage 3 hypoxic-ischaemic injury (AIRR=1.20; 95% CI 1.04, 1.39), length of hospital stay (AIRR=1.01; 95% CI 1.01, 1.03) and macrosomia (AIRR=1.39; 95% CI 1.19, 1.63) were significant factors associated with recurrence of hypoglycaemia.
Conclusions and recommendations: The current study indicated that the mean recurrence of hypoglycaemia in newborns experiencing perinatal asphyxia was considerably higher. Presence of neonatal meningitis, delayed initiation of feeding 72 hours after birth, stage 3 hypoxic-ischaemic injury, length of hospital stay and macrosomia were the key factors associated with recurrence of hypoglycaemia.
目的：了解2024年埃塞俄比亚西北部阿姆哈拉地区综合性专科医院新生儿重症监护病房收治的新生儿低血糖复发率及其相关因素。设计：一项多中心、以机构为基础的回顾性随访研究。环境：2020年7月1日至2024年7月30日，埃塞俄比亚西北部阿姆哈拉西北地区州的三级医院。对象：于2020年7月至2024年7月在阿姆哈拉西北部选定的公立医院新生儿重症监护室共收治围产期窒息新生儿761例。结局指标：本研究的主要结局指标是低血糖的复发。此外，还指出了围产期窒息新生儿低血糖复发的相关因素。结果：在28天的随访期间，出生窒息新生儿低血糖病例的平均数量为2.05例（95% CI 1.939, 2.163）。脑膜炎(调整后发病率比(AIRR)=1.16；95% CI 1.04, 1.30)，喂养时间小于72小时(AIRR=1.17；95% CI 1.05, 1.31)， 3期缺氧缺血性损伤(AIRR=1.20；95% CI 1.04, 1.39)、住院时间(AIRR=1.01；95% CI 1.01, 1.03)和巨大儿(AIRR=1.39；95% CI 1.19, 1.63)是与低血糖复发相关的重要因素。结论和建议：目前的研究表明，经历围产期窒息的新生儿低血糖的平均复发率相当高。新生儿脑膜炎的存在、出生后72小时延迟开始喂养、3期缺氧缺血性损伤、住院时间和巨大儿是低血糖复发的关键因素。
期刊介绍：
BMJ Open is an online, open access journal, dedicated to publishing medical research from all disciplines and therapeutic areas. The journal publishes all research study types, from study protocols to phase I trials to meta-analyses, including small or specialist studies. Publishing procedures are built around fully open peer review and continuous publication, publishing research online as soon as the article is ready.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
