{"title":"The dynamic roles of macrophages extracellular traps (METs) in immune regulation.","authors":"Yunjin Shin, Hanyoung Bae, Chaelin Lee, Inmoo Rhee","doi":"10.1007/s12272-025-01540-6","DOIUrl":null,"url":null,"abstract":"<p><p>Macrophages are crucial to innate immunity, eliminating pathogens and damaged tissues through phagocytosis and modulating immune responses. Recently, macrophage extracellular traps (METs) have been identified as chromatin-based structures composed of DNA and various immune-related proteins. While METs play a defensive role in trapping and neutralizing pathogens, they are also implicated in disease pathology, contributing to chronic inflammation, tissue damage, and immune dysregulation. The precise mechanisms regulating MET formation are still under investigation, but emerging evidence indicates the involvement of various regulatory factors. Dysregulated MET activity has been associated with various diseases, including autoimmune disorders, cancer, and neurological conditions. A deeper understanding of MET mechanisms and their pathological impact may offer novel therapeutic strategies. Given the limited number of reviews and articles on METs, this review provides valuable insights into MET formation, regulatory pathways, and their role in disease progression.</p>","PeriodicalId":8287,"journal":{"name":"Archives of Pharmacal Research","volume":" ","pages":""},"PeriodicalIF":6.9000,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of Pharmacal Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s12272-025-01540-6","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Macrophages are crucial to innate immunity, eliminating pathogens and damaged tissues through phagocytosis and modulating immune responses. Recently, macrophage extracellular traps (METs) have been identified as chromatin-based structures composed of DNA and various immune-related proteins. While METs play a defensive role in trapping and neutralizing pathogens, they are also implicated in disease pathology, contributing to chronic inflammation, tissue damage, and immune dysregulation. The precise mechanisms regulating MET formation are still under investigation, but emerging evidence indicates the involvement of various regulatory factors. Dysregulated MET activity has been associated with various diseases, including autoimmune disorders, cancer, and neurological conditions. A deeper understanding of MET mechanisms and their pathological impact may offer novel therapeutic strategies. Given the limited number of reviews and articles on METs, this review provides valuable insights into MET formation, regulatory pathways, and their role in disease progression.
巨噬细胞对先天性免疫至关重要，它通过吞噬作用消灭病原体和受损组织，并调节免疫反应。最近，人们发现巨噬细胞胞外捕获器（METs）是由 DNA 和各种免疫相关蛋白组成的染色质结构。虽然巨噬细胞胞外捕获器在捕获和中和病原体方面发挥着防御作用，但它们也与疾病病理有关，导致慢性炎症、组织损伤和免疫失调。调节 MET 形成的确切机制仍在研究之中，但新出现的证据表明有多种调节因子参与其中。MET 活性失调与多种疾病有关，包括自身免疫性疾病、癌症和神经系统疾病。深入了解 MET 的机制及其对病理的影响可能会提供新的治疗策略。鉴于有关 MET 的综述和文章数量有限，本综述提供了有关 MET 的形成、调控途径及其在疾病进展中的作用的宝贵见解。
期刊介绍：
Archives of Pharmacal Research is the official journal of the Pharmaceutical Society of Korea and has been published since 1976. Archives of Pharmacal Research is an interdisciplinary journal devoted to the publication of original scientific research papers and reviews in the fields of drug discovery, drug development, and drug actions with a view to providing fundamental and novel information on drugs and drug candidates.
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