A Time-Scheduled Oxygen Modulation System Facilitates Bone Regeneration by Powering Periosteal Stem Cells

IF 17.2 1区工程技术 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Advanced Fiber Materials Pub Date : 2025-01-28 DOI:10.1007/s42765-025-00509-w

Yujie Yang, Xue Gao, Yongfeng Zhang, Shengyou Li, Haining Wu, Bing Xia, Yiming Hao, Beibei Yu, Xueli Gao, Dan Geng, Lingli Guo, Mingze Qin, Yitao Wei, Borui Xue, Shijie Yang, Qi Liu, Shihao Nie, Anhui Qin, Jinya Liu, Lei Lu, Teng Ma, Zhuojing Luo, Jinghui Huang

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引用次数: 0

Abstract

Chronic hypoxia affects stem cell function during tissue repair. Thus far, the hypoxia-associated impact on periosteal stem cells (PSCs), the main contributor to bone repair, remains unknown, and a tailored oxygen modulation strategy for optimizing PSC function is lacking. Here, PSCs exhibit time-dependent proliferation and survival upon hypoxic exposure and a critical 48-h time-point is identified at which hypoxia transitions from beneficial to detrimental. Then, a photothermal-sensitive coaxial fiber-reinforced membrane containing oxygen and pravastatin is constructed to function as an intelligent oxygen supply system. Leveraging near-infrared light as an ON/OFF switch, the system noninvasively scales up oxygen release beginning 48 h post-implantation, counteracting prolonged hypoxia and mitigating its adverse effects on PSCs. The sustained release of pravastatin from the membrane accelerates early neovascularization both directly through its pro-angiogenic effect and indirectly by stimulating vascular endothelial growth factor secretion from PSCs, ensuring a continuous oxygen supply after exogenous oxygen exhaustion. Notably, pravastatin steers PSCs toward robust osteogenic differentiation and provides multifunctional bioactive cues for advanced bone regeneration in vivo. This time-scheduled approach to modulate oxygen supply noninvasively could be applicable beyond bone regeneration for hypoxia-related diseases and multi-tissue repair.

Graphical Abstract

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定时氧调节系统促进骨膜干细胞的骨再生

慢性缺氧影响干细胞在组织修复过程中的功能。到目前为止，缺氧对骨膜干细胞（PSCs）（骨修复的主要贡献者）的相关影响仍然未知，并且缺乏量身定制的氧调节策略来优化PSC功能。在这里，PSCs在缺氧暴露下表现出时间依赖性的增殖和存活，并且确定了一个关键的48小时时间点，在这个时间点上缺氧从有益转变为有害。然后，构建了一种含有氧和普伐他汀的光热敏同轴纤维增强膜，作为智能供氧系统。利用近红外光作为开/关开关，该系统在植入后48小时开始无创地扩大氧气释放，抵消长期缺氧，减轻其对psc的不利影响。普伐他汀从膜上的持续释放可通过其促血管生成作用直接加速早期新生血管形成，也可通过刺激PSCs分泌血管内皮生长因子间接加速早期新生血管形成，从而确保外源性氧衰竭后的持续供氧。值得注意的是，普伐他汀可以引导PSCs向强大的成骨分化方向发展，并为体内高级骨再生提供多功能生物活性线索。这种定时的无创调节氧供应的方法可以应用于缺氧相关疾病和多组织修复的骨再生。图形抽象

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来源期刊

Advanced Fiber Materials Multiple-

CiteScore

18.70

自引率

11.20%

发文量

109

期刊介绍： Advanced Fiber Materials is a hybrid, peer-reviewed, international and interdisciplinary research journal which aims to publish the most important papers in fibers and fiber-related devices as well as their applications.Indexed by SCIE, EI, Scopus et al. Publishing on fiber or fiber-related materials, technology, engineering and application.