Advances in the use of nanoparticles for specific cell-target delivery of anti-cancer agents

Abstract

In recent decades, cancer has emerged as one of the leading causes of death in developed countries. To revert this progression, scientists have focused on the design of new strategies for early detection of this disease and the development of more effective treatments for its eradication. Regarding the latter, one of the main research efforts has been directed toward designing more specific delivery systems for the administration of anti-tumoral agents. In this sense, the efficacy of conventional therapies used for cancer treatment, such as chemotherapy, immune checkpoint inhibitors and radiation therapy, are often limited by their lack of specificity and their potential to cause adverse secondary effects on healthy tissues. Therefore, designing specific cell-targeted delivery systems for anti-tumoral agents presents a promising approach to overcoming the limitations of conventional cancer therapies. In this review we summarize the advances in the use of nanoparticles for Specific Cell-Target Delivery of anti-tumoral agents from in vitro to clinical studies.