Yasmin Ezzatvar, José Francisco López-Gil, Rodrigo Yáñez-Sepúlveda, Jorge Olivares-Arancibia, Jacqueline Páez-Herrera, Antonio García-Hermoso
{"title":"Physical Activity is Related to Lower Levels of Neurofilament Light and Plasma Tau Protein: A 22-Year Follow-Up Study From Adolescence to Adulthood.","authors":"Yasmin Ezzatvar, José Francisco López-Gil, Rodrigo Yáñez-Sepúlveda, Jorge Olivares-Arancibia, Jacqueline Páez-Herrera, Antonio García-Hermoso","doi":"10.1016/j.jadohealth.2025.02.003","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the association between physical activity (PA) and neurodegeneration biomarkers from adolescence to adulthood by examining tau protein and neurofilament light chain (NfL) levels in blood samples.</p><p><strong>Methods: </strong>The study analyzed data from adolescents aged 12-19 years who participated in Waves I (1994-1996) and V (2016-2018) of the Add Health study over a span of 22 years. It assessed PA through self-reported questionnaires. Neurodegeneration measures at Wave V used venous blood collected via phlebotomy. Samples were analyzed using single-molecule array (Simoa) technology on a Quanterix HD-1 analyzer, using digital enzyme-linked immunosorbent assay to quantify NfL and tau proteins from serum and plasma samples.</p><p><strong>Results: </strong>In the present study, 3,182 individuals participated, with females comprising 61% of the sample. Participants adhering to the PA guidelines in both waves reported lower levels of NfL (-0.583 pg/mL, 95% bias-corrected and accelerated (BCa) confidence interval (CI): -1.235 to -0.068) and tau protein levels (-0.244 pg/mL, 95% BCa CI: -0.405 to -0.078). Adjusted analyses confirmed significant lower levels of tau protein (-0.210 pg/mL, 95% BCa CI: -0.350 to -0.072) for Wave I adherents and even lower levels in NfL (-0.421 pg/mL, 95% BCa CI: -0.929 to -0.007) and tau protein levels (-0.229 pg/mL, 95% BCa CI: -0.412 to -0.053) for active participants in both waves.</p><p><strong>Discussion: </strong>Our findings suggest that consistent engagement in PA may reduce certain neurodegenerative biomarkers, potentially influencing neurological health outcomes.</p>","PeriodicalId":56278,"journal":{"name":"Journal of Adolescent Health","volume":" ","pages":""},"PeriodicalIF":5.5000,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Adolescent Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jadohealth.2025.02.003","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PEDIATRICS","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose: To investigate the association between physical activity (PA) and neurodegeneration biomarkers from adolescence to adulthood by examining tau protein and neurofilament light chain (NfL) levels in blood samples.
Methods: The study analyzed data from adolescents aged 12-19 years who participated in Waves I (1994-1996) and V (2016-2018) of the Add Health study over a span of 22 years. It assessed PA through self-reported questionnaires. Neurodegeneration measures at Wave V used venous blood collected via phlebotomy. Samples were analyzed using single-molecule array (Simoa) technology on a Quanterix HD-1 analyzer, using digital enzyme-linked immunosorbent assay to quantify NfL and tau proteins from serum and plasma samples.
Results: In the present study, 3,182 individuals participated, with females comprising 61% of the sample. Participants adhering to the PA guidelines in both waves reported lower levels of NfL (-0.583 pg/mL, 95% bias-corrected and accelerated (BCa) confidence interval (CI): -1.235 to -0.068) and tau protein levels (-0.244 pg/mL, 95% BCa CI: -0.405 to -0.078). Adjusted analyses confirmed significant lower levels of tau protein (-0.210 pg/mL, 95% BCa CI: -0.350 to -0.072) for Wave I adherents and even lower levels in NfL (-0.421 pg/mL, 95% BCa CI: -0.929 to -0.007) and tau protein levels (-0.229 pg/mL, 95% BCa CI: -0.412 to -0.053) for active participants in both waves.
Discussion: Our findings suggest that consistent engagement in PA may reduce certain neurodegenerative biomarkers, potentially influencing neurological health outcomes.
期刊介绍：
The Journal of Adolescent Health is a scientific publication dedicated to enhancing the health and well-being of adolescents and young adults. Our Journal covers a broad range of research topics, spanning from the basic biological and behavioral sciences to public health and policy. We welcome a variety of contributions, including original research papers, concise reports, literature reviews, clinical case reports, opinion pieces, and letters to the editor. We encourage professionals from diverse disciplines such as Anthropology, Education, Ethics, Global Health, Health Services Research, Law, Medicine, Mental and Behavioral Health, Nursing, Nutrition, Psychology, Public Health and Policy, Social Work, Sociology, and Youth Development to share their expertise and contribute to our mission of promoting adolescent health. Moreover, we value the voices of young individuals, family and community members, and healthcare professionals, and encourage them to submit poetry, personal narratives, images, and other creative works that provide unique insights into the experiences of adolescents and young adults. By combining scientific peer-reviewed research with creative expressions, our Journal aims to create a comprehensive understanding of the challenges and opportunities in adolescent and young adult health.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
