{"title":"Supranuclear Disorders of Eye Movements.","authors":"Gregory P Van Stavern","doi":"10.1212/CON.0000000000001558","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This article reviews the basic anatomy and pathophysiology of the supranuclear ocular motor pathways, emphasizing clinical correlations.</p><p><strong>Latest developments: </strong>More advanced neuroimaging, particularly functional MRI, has yielded insight into previously unclear mechanisms of eye movement control with potential clinical implications. A better understanding of the mechanisms of eye movement control has implications for translational research, resulting in improved and early diagnosis and better treatment options.</p><p><strong>Essential points: </strong>Dysfunction of the supranuclear ocular motor pathways typically causes highly localizable deficits. With relative ease of access to sophisticated neuroimaging, it is critical to better understand structure-function relationships and precisely localize pathology within the brain. Accurately localizing a lesion in the supranuclear ocular motor pathways might prevent delay in diagnosis and misdiagnosis, and in some cases allow for early recognition of neurodegenerative diseases.</p>","PeriodicalId":52475,"journal":{"name":"CONTINUUM Lifelong Learning in Neurology","volume":"31 2","pages":"479-502"},"PeriodicalIF":0.0000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"CONTINUUM Lifelong Learning in Neurology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1212/CON.0000000000001558","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: This article reviews the basic anatomy and pathophysiology of the supranuclear ocular motor pathways, emphasizing clinical correlations.
Latest developments: More advanced neuroimaging, particularly functional MRI, has yielded insight into previously unclear mechanisms of eye movement control with potential clinical implications. A better understanding of the mechanisms of eye movement control has implications for translational research, resulting in improved and early diagnosis and better treatment options.
Essential points: Dysfunction of the supranuclear ocular motor pathways typically causes highly localizable deficits. With relative ease of access to sophisticated neuroimaging, it is critical to better understand structure-function relationships and precisely localize pathology within the brain. Accurately localizing a lesion in the supranuclear ocular motor pathways might prevent delay in diagnosis and misdiagnosis, and in some cases allow for early recognition of neurodegenerative diseases.
期刊介绍：
Continue your professional development on your own schedule with Continuum: Lifelong Learning in Neurology®, the American Academy of Neurology" self-study continuing medical education publication. Six times a year you"ll learn from neurology"s experts in a convenient format for home or office. Each issue includes diagnostic and treatment outlines, clinical case studies, a topic-relevant ethics case, detailed patient management problem, and a multiple-choice self-assessment examination.
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