Clinical Impact of Primary Sclerosing Cholangitis on Outcomes of Inflammatory Bowel Disease Hospitalization: A Propensity Score Matching Analysis of the Nationwide Inpatient Sample

IF 2.3 3区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY

Journal of Digestive Diseases Pub Date : 2025-04-04 DOI:10.1111/1751-2980.13339

Xing Yu, Juan Guo, Meng Li Xue, Cheng Dang Wang, Wei Wei Zheng

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引用次数: 0

Abstract

Objective

We aimed to evaluate the effect of primary sclerosing cholangitis (PSC) on hospitalization outcomes of inflammatory bowel disease (IBD) patients.

Methods

This retrospective study used data from the Nationwide Inpatient Sample (NIS) database from January 1, 2019, to December 31, 2020, including adults (≥ 18 years) admitted and diagnosed with IBD. Key outcomes included length of hospital stay (LOS), in-hospital mortality, hospitalization cost, and complications. The propensity score matching (PSM) analysis was used to balance characteristics between IBD patients with and without PSC, followed by logistic regression for analysis.

Results

After PSM analysis, 4950 patients (PSC: 990; non-PSC: 3960) were analyzed. IBD patients with PSC showed higher odds of any complication (odds ratio [OR] 2.08, 95% confidence interval [CI] 1.80–2.39), including acute kidney injury (OR 1.31, 95% CI 1.10–1.55), septic shock (OR 1.84, 95% CI 1.33–2.54), liver cirrhosis (OR 18.19, 95% CI 14.23–23.25), and liver failure (OR 8.33, 95% CI 5.93–11.70) (all p < 0.05). These associations were consistently observed across subgroups with stronger associations in the Crohn's disease subgroup.

Conclusions

PSC significantly increases the risk of short-term complications in hospitalized IBD patients and the likelihood of chronic liver disease-related complications. These findings highlight the need for targeted management strategies for IBD patients with co-existing PSC.

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原发性硬化性胆管炎对炎症性肠病住院治疗结果的临床影响：全国住院患者样本的倾向评分匹配分析

目的：探讨原发性硬化性胆管炎（PSC）对炎症性肠病（IBD）患者住院结局的影响。方法：本回顾性研究使用了2019年1月1日至2020年12月31日全国住院患者样本（NIS）数据库的数据，包括入院并诊断为IBD的成年人（≥18岁）。主要结局包括住院时间（LOS）、住院死亡率、住院费用和并发症。使用倾向评分匹配（PSM）分析来平衡伴有和不伴有PSC的IBD患者的特征，然后进行逻辑回归分析。结果：经PSM分析，4950例患者(PSC: 990；非psc: 3960)进行分析。IBD合并PSC患者出现任何并发症的几率更高（比值比[OR] 2.08, 95%可信区间[CI] 1.80-2.39），包括急性肾损伤（OR 1.31, 95% CI 1.10-1.55）、感染性休克（OR 1.84, 95% CI 1.33-2.54）、肝硬化（OR 18.19, 95% CI 14.23-23.25）和肝功能衰竭（OR 8.33, 95% CI 5.93-11.70）（均为p）。PSC显著增加IBD住院患者短期并发症的风险和慢性肝病相关并发症的可能性。这些发现强调了IBD合并PSC患者需要有针对性的管理策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Digestive Diseases 医学-胃肠肝病学

CiteScore

5.40

自引率

2.90%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal of Digestive Diseases is the official English-language journal of the Chinese Society of Gastroenterology. The journal is published twelve times per year and includes peer-reviewed original papers, review articles and commentaries concerned with research relating to the esophagus, stomach, small intestine, colon, liver, biliary tract and pancreas.