Clinical presentation of Oropouche virus infection: A systematic review and meta-analysis.

IF 3.4 2区医学 Q1 PARASITOLOGY

PLoS Neglected Tropical Diseases Pub Date : 2025-04-02 eCollection Date: 2025-04-01 DOI:10.1371/journal.pntd.0012962

Zhilin Wang, Linzhu Huang, Xinyu Zhang, Xinyue Zhang, Liwei Huang, Xiaoying Zhu, Xidai Long, Demin Cao, Yulei Li

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引用次数: 0

Abstract

Background: The recent surge in incidence and geographic spread of OROV infections poses an escalating threat to global public health. However, studies exploring the clinical signs of OROV infection remains exceedingly limited.

Methods: We searched for OROV studies published until June 17, 2024, in several electronic databases including MEDLINE, EMBASE, SCOPUS, and the Cochrane Library.

Results: In total, 15 studies involving 806 patients with OROV infection were eligible for inclusion. General symptoms with fever and headache were the most common. Gastrointestinal disturbances like nausea/vomiting, anorexia, and odynophagia were also prevalent, along with ocular symptoms, mainly retro-orbital pain, photophobia, and redness. Respiratory symptoms, such as cough, sore throat and nasal congestion, are present, and skin-related issues like rash, pruritus, and pallor were also identified.

Conclusion: Overall, this study provides a foundational understanding of OROV's clinical manifestations to guide diagnosis, management, and public health interventions against this neglected tropical disease.

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Oropouche病毒感染的临床表现：系统回顾和荟萃分析。

背景：最近OROV感染的发病率和地理传播的激增对全球公共卫生构成了不断升级的威胁。然而，探索OROV感染的临床症状的研究仍然非常有限。方法：我们在MEDLINE、EMBASE、SCOPUS和Cochrane Library等多个电子数据库中检索到2024年6月17日之前发表的OROV研究。结果：总共有15项涉及806例OROV感染患者的研究符合纳入条件。一般症状以发烧和头痛最为常见。胃肠道紊乱，如恶心/呕吐、厌食和厌食症也很普遍，同时眼部症状，主要是眶后疼痛、畏光和发红。呼吸道症状，如咳嗽、喉咙痛和鼻塞，以及皮肤相关问题，如皮疹、瘙痒和苍白也被确定。结论：总的来说，本研究为了解OROV的临床表现提供了基础，以指导这种被忽视的热带病的诊断、管理和公共卫生干预。

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来源期刊

PLoS Neglected Tropical Diseases PARASITOLOGY-TROPICAL MEDICINE

自引率

10.50%

发文量

723

期刊介绍： PLOS Neglected Tropical Diseases publishes research devoted to the pathology, epidemiology, prevention, treatment and control of the neglected tropical diseases (NTDs), as well as relevant public policy. The NTDs are defined as a group of poverty-promoting chronic infectious diseases, which primarily occur in rural areas and poor urban areas of low-income and middle-income countries. Their impact on child health and development, pregnancy, and worker productivity, as well as their stigmatizing features limit economic stability. All aspects of these diseases are considered, including: Pathogenesis Clinical features Pharmacology and treatment Diagnosis Epidemiology Vector biology Vaccinology and prevention Demographic, ecological and social determinants Public health and policy aspects (including cost-effectiveness analyses).