Zahra Esmaeili, Sara Kamal Shahsavar, Kiarash Ghazvini
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引用次数: 0
Abstract
The overuse of antibiotics worldwide, especially during the Coronavirus pandemic, has raised concerns about the rise of antibiotic resistance and its side effects. Immunoglobulin Y, a natural protein that specifically targets foreign antigens, holds promise as a potential therapeutic option, particularly for individuals with sensitive immune systems. Despite numerous studies on IgY, the optimal administration method, effective dose, target antigen, and potential side effects of this antibody remain areas of active research and challenge. This review selected and evaluated articles published in the last ten years from databases such as PubMed and Science Direct with appropriate keywords discussing the therapeutic effects of immunoglobulin Y in human infections in vivo. Out of all the reviewed articles, 35 articles met the inclusion criteria. The results showed that the specific antibody against dental, respiratory, and skin infections has an acceptable effectiveness. In contrast, some infections, such as neurological infections, including tetanus and botulism, still need further investigation due to the short survival time of mice. On the other hand, reporting side effects such as antibody-dependent enhancement in some infections limits its use.
全球范围内抗生素的过度使用,尤其是在冠状病毒大流行期间,引起了人们对抗生素耐药性及其副作用的担忧。免疫球蛋白 Y 是一种专门针对外来抗原的天然蛋白质,有望成为一种潜在的治疗选择,特别是对于免疫系统敏感的人来说。尽管对 IgY 进行了大量研究,但这种抗体的最佳给药方法、有效剂量、靶抗原和潜在副作用仍是目前研究和挑战的领域。本综述从 PubMed 和 Science Direct 等数据库中选取了过去十年发表的文章,并用适当的关键词进行了评估,这些文章讨论了免疫球蛋白 Y 在人体感染中的治疗效果。在所有审查过的文章中,有 35 篇符合纳入标准。结果显示,针对牙科、呼吸道和皮肤感染的特异性抗体具有可接受的疗效。相比之下,由于小鼠存活时间较短,一些感染,如神经系统感染(包括破伤风和肉毒中毒)仍需进一步研究。另一方面,抗体依赖性增强等副作用也限制了它的使用。