Extracellular vesicles as a source of biomarkers in hematological malignancies: looking toward clinical appilcations.

IF 3.9 3区医学 Q1 PATHOLOGY

Expert Review of Molecular Diagnostics Pub Date : 2025-04-03 DOI:10.1080/14737159.2025.2488919

Claudia Ielo, Massimo Breccia

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引用次数: 0

Abstract

Introduction: Extracellular vesicles are membranous particles released by cells in physiological and pathological conditions. Their cargo is heterogeneous since it includes different biomolecules such as nucleic acids and proteins. Oncogenic alterations affect the composition of extracellular vesicles and model their content during cancer evolution.

Areas covered: This review provides an overview of the studies focused on extracellular vesicles as source of biomarkers in hematological malignancies. A special insight into extracellular vesicles-derived biomarkers as tools for evaluating the prognosis of hematological malignancies and their response to treatment is given.

Expert opinion: Extracellular vesicles are a valuable source of biomarkers in hematological malignancies. However, the translation from the bench to the bedside is challenged by the lack of standardization of the preanalytical variables of the experimental workflow. The release of standard operating procedures and the validation of the extracellular vesicles-derived biomarkers in large cohort of patients will help in exploiting the potential of extracellular vesicles in the clinical setting.

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细胞外囊泡作为血液恶性肿瘤生物标志物的来源：展望临床应用。

细胞外囊泡是细胞在生理和病理状态下释放的膜状颗粒。他们的货物是异质的，因为它包括不同的生物分子，如核酸和蛋白质。致癌改变影响细胞外囊泡的组成，并在癌症进化过程中模拟其内容。涵盖领域：本综述综述了细胞外囊泡作为血液系统恶性肿瘤生物标志物来源的研究。对细胞外囊泡衍生的生物标志物作为评估血液学恶性肿瘤预后及其对治疗反应的工具的特殊见解。专家意见：细胞外囊泡是血液学恶性肿瘤生物标志物的宝贵来源。然而，从工作台到床边的转换受到缺乏标准化的实验工作流程的分析前变量的挑战。标准操作程序的发布和在大量患者中验证细胞外囊泡衍生的生物标志物将有助于开发细胞外囊泡在临床环境中的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Molecular Diagnostics 医学-病理学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Expert Review of Molecular Diagnostics (ISSN 1473-7159) publishes expert reviews of the latest advancements in the field of molecular diagnostics including the detection and monitoring of the molecular causes of disease that are being translated into groundbreaking diagnostic and prognostic technologies to be used in the clinical diagnostic setting. Each issue of Expert Review of Molecular Diagnostics contains leading reviews on current and emerging topics relating to molecular diagnostics, subject to a rigorous peer review process; editorials discussing contentious issues in the field; diagnostic profiles featuring independent, expert evaluations of diagnostic tests; meeting reports of recent molecular diagnostics conferences and key paper evaluations featuring assessments of significant, recently published articles from specialists in molecular diagnostic therapy. Expert Review of Molecular Diagnostics provides the forum for reporting the critical advances being made in this ever-expanding field, as well as the major challenges ahead in their clinical implementation. The journal delivers this information in concise, at-a-glance article formats: invaluable to a time-constrained community.