Effect of 4 Weeks Resonance Frequency Breathing on Glucose Metabolism and Autonomic Tone in Healthy Adults.

IF 6.8 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Benedict Herhaus, Andreas Peter, Julia Hummel, Thomas Kubiak, Martin Heni, Katja Petrowski
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Abstract

Background: The autonomic nervous system plays a crucial role in the brain's communication with metabolically important peripheral organs, modulating insulin sensitivity and secretion. Increased sympathetic tone is a common feature in prediabetes and diabetes. The parasympathetic nervous system activity might be improvable through resonance frequency breathing (RFB) with heart rate variability biofeedback (HRV-BF) training.

Methods: We here investigated the effect of a 4-week mobile RFB-HRV-BF intervention on glucose metabolism and HRV of 30 healthy adults (17 females; mean age 25.77±3.64 years; mean body mass index 22.65±2.95 kg/m2). Before and after the intervention, glucose metabolism was assessed by 75 g oral glucose tolerance tests (with blood sampling every 30 minutes over 2 hours) and HRV was measured through electrocardiography.

Results: RFB-HRV-BF training did not influence glucose metabolism in healthy adults but reduced fasting as well as 2-hour-postload glucose in participants categorized as more insulin resistant before the intervention. In addition, RFB-HRV-BF training was associated with an increase in the time and frequency domain HRV parameters standard deviation of all NN-intervals, root mean square successive differences, HRV high-frequency and HRV low-frequency after 4 weeks of intervention.

Conclusion: Our findings introduce RFB-HRV-BF training as an effective tool to modulate the autonomic nervous system with a shift towards the parasympathetic tone. Along with the observed decrease in glycemia in those with lower insulin sensitivity, RFB-HRV-BF training emerges as a promising non-pharmacological approach to improve glucose metabolism which has to be further investigated in prediabetes and diabetes.

4周共振频率呼吸对健康成人葡萄糖代谢和自主神经张力的影响。
背景:自主神经系统在大脑与代谢重要的外周器官的交流中起着至关重要的作用,调节胰岛素敏感性和分泌。交感神经张力增加是糖尿病前期和糖尿病的共同特征。通过共振频率呼吸(RFB)和心率变异性生物反馈(HRV-BF)训练可以改善副交感神经系统的活动。方法:我们研究了为期4周的RFB-HRV-BF移动干预对30名健康成人(17名女性;平均年龄25.77±3.64岁;平均体重指数(22.65±2.95 kg/m2)。干预前后,通过75 g口服葡萄糖耐量试验(2小时内每30分钟采血一次)评估糖代谢,通过心电图测量HRV。结果:RFB-HRV-BF训练对健康成人的葡萄糖代谢没有影响,但在干预前胰岛素抵抗性较高的参与者中,空腹和负荷后2小时葡萄糖水平降低。此外,RFB-HRV-BF训练与干预4周后所有nn区间HRV参数的时域和频域标准差、均方根连续差、HRV高频和HRV低频的增加有关。结论:我们的研究结果表明RFB-HRV-BF训练是调节自主神经系统向副交感神经张力转变的有效工具。随着胰岛素敏感性较低的患者血糖下降,RFB-HRV-BF训练成为一种很有前景的改善葡萄糖代谢的非药物方法,有待于在糖尿病前期和糖尿病中进一步研究。
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来源期刊
Diabetes & Metabolism Journal
Diabetes & Metabolism Journal Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
10.40
自引率
6.80%
发文量
92
审稿时长
52 weeks
期刊介绍: The aims of the Diabetes & Metabolism Journal are to contribute to the cure of and education about diabetes mellitus, and the advancement of diabetology through the sharing of scientific information on the latest developments in diabetology among members of the Korean Diabetes Association and other international societies. The Journal publishes articles on basic and clinical studies, focusing on areas such as metabolism, epidemiology, pathogenesis, complications, and treatments relevant to diabetes mellitus. It also publishes articles covering obesity and cardiovascular disease. Articles on translational research and timely issues including ubiquitous care or new technology in the management of diabetes and metabolic disorders are welcome. In addition, genome research, meta-analysis, and randomized controlled studies are welcome for publication. The editorial board invites articles from international research or clinical study groups. Publication is determined by the editors and peer reviewers, who are experts in their specific fields of diabetology.
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