Deep learning: A game changer in drug design and development.

Q1 Pharmacology, Toxicology and Pharmaceutics
Advances in pharmacology Pub Date : 2025-01-01 Epub Date: 2025-02-06 DOI:10.1016/bs.apha.2025.01.008
Sushanta Kumar Das, Rahul Mishra, Amit Samanta, Dibyendu Shil, Saumendu Deb Roy
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引用次数: 0

Abstract

The lengthy and costly drug discovery process is transformed by deep learning, a subfield of artificial intelligence. Deep learning technologies expedite the procedure, increasing treatment success rates and speeding life-saving procedures. Deep learning stands out in target identification and lead selection. Deep learning greatly accelerates initial stage by analyzing large datasets of biological data to identify possible therapeutic targets and rank targeted drug molecules with desired features. Predicting possible adverse effects is another significant challenge. Deep learning offers prompt and efficient assistance with toxicology prediction in a very short time, deep learning algorithms can forecast a new drug's possible harm. This enables to concentrate on safer alternatives and steer clear of late-stage failures brought on by unanticipated toxicity. Deep learning unlocks the possibility of drug repurposing; by examining currently available medications, it is possible to find whole new therapeutic uses. This method speeds up development of diseases that were previously incurable. De novo drug discovery is made possible by deep learning when combined with sophisticated computational modeling, it can create completely new medications from the ground. Deep learning can recommend and direct towards new drug candidates with high binding affinities and intended therapeutic effects by examining molecular structures of disease targets. This provides focused and personalized medication. Lastly, drug characteristics can be optimized with aid of deep learning. Researchers can create medications with higher bioavailability and fewer toxicity by forecasting drug pharmacokinetics. In conclusion, deep learning promises to accelerate drug development, reduce costs, and ultimately save lives.

深度学习:改变药物设计和开发的游戏规则。
人工智能的一个子领域——深度学习改变了漫长而昂贵的药物发现过程。深度学习技术加快了治疗过程,提高了治疗成功率,加快了挽救生命的过程。深度学习在目标识别和领导选择中脱颖而出。深度学习通过分析大型生物数据集来识别可能的治疗靶点,并根据所需的特征对靶向药物分子进行排序,从而大大加快了初始阶段。预测可能的副作用是另一个重大挑战。深度学习在很短的时间内为毒理学预测提供了快速有效的帮助,深度学习算法可以预测新药可能的危害。这使得人们能够专注于更安全的替代方案,并避免因意外毒性而导致的后期失败。深度学习开启了药物再利用的可能性;通过检查目前可用的药物,有可能发现全新的治疗用途。这种方法加速了以前无法治愈的疾病的发展。通过深度学习与复杂的计算模型相结合,可以从头开始创造全新的药物。深度学习可以通过检查疾病靶点的分子结构来推荐和指导具有高结合亲和力和预期治疗效果的新候选药物。这提供了集中和个性化的治疗。最后,药物特性可以借助深度学习进行优化。研究人员可以通过预测药物的药代动力学来创造具有更高生物利用度和更低毒性的药物。总之,深度学习有望加速药物开发,降低成本,并最终拯救生命。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Advances in pharmacology
Advances in pharmacology Pharmacology, Toxicology and Pharmaceutics-Pharmacology
CiteScore
9.10
自引率
0.00%
发文量
45
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