Unravelling the impact of the chromobox proteins in human cancers.

IF 8.1 1区生物学 Q1 CELL BIOLOGY

Cell Death & Disease Pub Date : 2025-04-02 DOI:10.1038/s41419-025-07585-1

Shabana Noreen, Nicla Simonelli, Rosaria Benedetti, Vincenzo Carafa, Michele Grieco, Concetta Ambrosino, Carmela Dell'Aversana, Angela Nebbioso, Mariarosaria Conte, Nunzio Del Gaudio, Lucia Altucci

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引用次数: 0

Abstract

Chromobox (CBX) proteins play a crucial role in regulating epigenetic processes. They are extensively involved in various biological processes, including embryonic development, stem cell maintenance, cell proliferation and apoptosis control. The disruption and malfunction of CBXs in cancer typically results in the interference or abnormal activation of developmental pathways, which facilitate the onset, growth, and advancement of cancer. This review initially introduces the physiological properties and functions of the CBXs. Subsequently, it examines the involvement of CBXs in different cancer types. Cancer hallmarks driven by CBXs are mediated through multiple mechanisms, including changes in gene expression patterns, epigenetic dysregulation of chromatin control, disruption of intracellular signaling and alterations in cell metabolism. The study also highlights novel potential anticancer therapeutics targeting CBXs in cancer. In this review we provide novel perspectives and a solid foundation for future investigations on CBXs as promising therapeutic targets for cancer treatment.

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揭示色盒蛋白对人类癌症的影响。

染色体盒（CBX）蛋白在调控表观遗传过程中发挥着至关重要的作用。它们广泛参与各种生物过程，包括胚胎发育、干细胞维持、细胞增殖和凋亡控制。在癌症中，CBX 的干扰和功能失常通常会导致发育途径的干扰或异常激活，从而促进癌症的发生、生长和发展。本综述首先介绍了 CBX 的生理特性和功能。随后，它探讨了 CBX 在不同癌症类型中的参与情况。由 CBXs 驱动的癌症特征是通过多种机制介导的，包括基因表达模式的改变、染色质控制的表观遗传失调、细胞内信号传导的破坏和细胞代谢的改变。该研究还强调了针对癌症中的 CBXs 的新型潜在抗癌疗法。在这篇综述中，我们提供了新的视角，并为今后将 CBXs 作为癌症治疗靶点的研究奠定了坚实的基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Death & Disease CELL BIOLOGY-

CiteScore

15.10

自引率

2.20%

发文量

935

审稿时长

2 months

期刊介绍： Brought to readers by the editorial team of Cell Death & Differentiation, Cell Death & Disease is an online peer-reviewed journal specializing in translational cell death research. It covers a wide range of topics in experimental and internal medicine, including cancer, immunity, neuroscience, and now cancer metabolism. Cell Death & Disease seeks to encompass the breadth of translational implications of cell death, and topics of particular concentration will include, but are not limited to, the following: Experimental medicine Cancer Immunity Internal medicine Neuroscience Cancer metabolism