Multiple Long-Term Conditions, Co-Long-Term Conditions and Polyvascular Disease: Considerations for Evidence Synthesis and Meta-Analyses

Gillian Mead, Alex Todhunter-Brown, Ukachukwu Abaraogu, Amanda Barugh, Arohi Chauhan, Juan Erviti Lopez, Valery Feigin, Jaya Singh Kshatri, Atsushi Mizuno, Sanghamitra Pati, Jackie Price, Rui Providência, Gerry Stansby, Rod Taylor, David J. Williams, James M. Wright, Simiao Wu, Leon Flicker
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Abstract

Cochrane's scientific strategy for 2025 to 2030 has four research priorities, including improving the lives of people living with multiple chronic conditions. The purpose of this article written by the Cochrane Thematic Group in Heart, Stroke and Circulation is to explore considerations around multiple chronic conditions (also referred to as ‘multiple long-term conditions’ i.e. two or more long-term conditions) in systematic reviews. Rather than using the term ‘comorbidity’, we introduce a new term ‘co-long-term conditions’. We also explore how to define ‘polyvascular disease’. We suggest that review authors consider co-long-term conditions and multiple long-term conditions in their reviews e.g. extract data about how primary studies address co-long-term conditions, perform subgroup analyses according to presence or not of co-long-term conditions, and include a section in the discussion about how well participants with co-long-term conditions were represented in the primary studies. This is especially pertinent for reviews addressing heart, circulatory or stroke disease, and polyvascular disease.

多重长期疾病、共同长期疾病和多血管疾病:对证据综合和荟萃分析的考虑
科克伦2025年至2030年的科学战略有四个研究重点,包括改善患有多种慢性疾病的人的生活。本文由Cochrane心脏、中风和循环专题小组撰写,目的是探讨在系统评价中对多种慢性疾病(也称为“多种长期疾病”,即两种或两种以上长期疾病)的考虑。我们不再使用“共病”这个术语,而是引入了一个新的术语“共同长期状况”。我们还探讨了如何定义“多血管疾病”。我们建议综述作者在其综述中考虑共同长期条件和多重长期条件,例如,提取有关主要研究如何处理共同长期条件的数据,根据是否存在共同长期条件进行亚组分析,并在讨论中包括关于共同长期条件参与者在主要研究中的代表性的部分。这尤其适用于心脏、循环系统或中风疾病和多血管疾病的综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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