Incidence of early neonatal sepsis and its predictor among low birthweight neonates in Northwest Ethiopia Comprehensive Specialized Hospitals, A retrospective follow-up study, 2024

Q2 Nursing

Journal of Neonatal Nursing Pub Date : 2025-04-04 DOI:10.1016/j.jnn.2025.101636

Wubet Tazeb Wondie , Chalachew Adugna Wubneh , Bruck Tesfaye Legesse , Sosina Tamre Mamo , Yeshimebet Tamir Tsehay , Mengistu Abebe Messelu , Henok Biresaw Netsere , Tiruye Azene Demile , Gebremeskel Kibret Abebe , Asnake Gashaw Belayneh , Alamirew Enyew Belay , Ousman Adal , Sileshi Mulatu , Gebrehiwot Berie Mekonnen

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引用次数: 0

Abstract

Background

Early onset neonatal sepsis is a significant public health concern. Notably, it escalates the suffering and mortality of low birth weight neonates in sub-Saharan frica. However, there are limited studies regarding sepsis and its predictors among these neonates in Ethiopia. Therefore, we aimed to assess the incidence of early neonatal sepsis and predictors among low birth weight neonates.

Methods

A retrospective follow-up study was conducted among 407 low birth weight neonates from September 1, 2021, to October 31, 2023, in Northwest Ethiopia. A data abstraction checklist was used for data collection, and a simple random sampling technique was employed. EPI-DATA™ 4.6.06, and STATA™ 14 were used for data entry and analysis respectively. Kaplan Meir cure and log-rank test were computed. Both bi-variable and multivariable Gompertz regression analyses were applied to identify significant predictors.

Results

The incidence of early-onset neonatal sepsis was found to be 15.6 (95% CI: 13.85–17.56) per 100 neonate's day observation. Spontaneous vaginal delivery (AHR = 2.42; 95%CI: 1.66–3.51), maternal history of UTI/STI (AHR:1.40; 95% CI; 1.05–1.86), resuscitation (AHR = 1.46; 95% CI; 1.12–1.89), perinatal asphyxia (AHR = 1.47; 95% CI:1.01–2.11) prematurity (AHR = 1.36; 95% CI: 1.02–1.80), and birth weight<1000 gm. (AHR = 2.15; 95% CI:1.12–4.14) were predictors.

Conclusions

The incidence of early-onset neonatal sepsis among low birth weight neonates was significantly high. Spontaneous vaginal delivery, maternal UTI/STI, resuscitation, perinatal asphyxia, prematurity, and birth weight <1000 were predictors. Hence, the stakeholders need to strictly implement the national infection prevention strategies and critically follow those high-risk neonates. In addition, mothers and neonates, need to be screened.

查看原文本刊更多论文

埃塞俄比亚西北部综合专科医院低出生体重新生儿早期脓毒症发病率及其预测因素，回顾性随访研究，2024

背景：早发新生儿败血症是一个重要的公共卫生问题。值得注意的是，它加剧了撒哈拉以南非洲低出生体重新生儿的痛苦和死亡率。然而，在埃塞俄比亚这些新生儿中，关于败血症及其预测因素的研究有限。因此，我们旨在评估低出生体重新生儿中早期新生儿脓毒症的发生率及其预测因素。方法对埃塞俄比亚西北部地区2021年9月1日至2023年10月31日的407例低出生体重新生儿进行回顾性随访研究。数据收集采用数据抽象检查表，采用简单的随机抽样技术。分别使用EPI-DATA™4.6.06和STATA™14进行数据录入和分析。计算Kaplan Meir治愈率和log-rank检验。采用双变量和多变量Gompertz回归分析来确定显著的预测因子。结果早发型新生儿脓毒症的发生率为15.6例/ 100例（95% CI: 13.85 ~ 17.56）。阴道自然分娩(AHR = 2.42；95%CI: 1.66-3.51)，产妇UTI/STI病史(AHR:1.40；95%可信区间;1.05 ~ 1.86)，复苏(AHR = 1.46；95%可信区间;1.12-1.89)，围产期窒息(AHR = 1.47；95% CI: 1.01-2.11)早产(AHR = 1.36；95% CI: 1.02-1.80)和出生体重1000克(AHR = 2.15；95% CI: 1.12-4.14)为预测因子。结论低出生体重儿早发性新生儿脓毒症发生率较高。阴道自然分娩、产妇尿路感染/性传播感染、复苏、围产期窒息、早产和出生体重是预测因素。因此，各利益攸关方需要严格执行国家感染预防战略，严格跟踪高危新生儿。此外，需要对母亲和新生儿进行筛查。

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来源期刊

Journal of Neonatal Nursing Nursing-Pediatrics

CiteScore

2.00

自引率

0.00%

发文量

143

期刊介绍： Aims & Scope: This is the practical, bimonthly, research-based journal for all professionals concerned with the care of neonates and their families, both in hospital and the community. It aims to support the development of the essential practice, management, education and health promotion skills required by these professionals. The JNN will provide a forum for the exchange of ideas and information between the range of professionals working in this field; promote cooperation between these professionals; facilitate partnership care with families; provide information and informed opinion; promote innovation and change in the care of neonates and their families; and provide an education resource for this important rapidly developing field.