Green biosynthesis of silver nanoparticles using anthocyanins-rich extract from Euterpe edulis fruits (AnthocyanOx®): assessment in vitro of antioxidant and antiglycation activities, and in silico anti-aging activity

IF 3.5 2区农林科学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Food and Bioproducts Processing Pub Date : 2025-04-01 DOI:10.1016/j.fbp.2025.03.017

Valter Henrique Marinho dos Santos , Monique Maria de Oliveira Costa , Filipe Oliveira Granero , Célia Cristina Malaguti Figueiredo , Hugo Henrique Santos , Paulo José Coelho Benevides , Nilson Nicolau-Junior , Paulo Eduardo Amaral Debiagi , Luciana Pereira Silva , Regildo Márcio Gonçalves da Silva

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Abstract

The standardized plant extract rich in anthocyanins (approximately 15,000 ppm) extracted from E. edulis fruits (AnthocyanOx®) has demonstrated potential uses and applications for the development of new products in food, cosmetic, and pharmaceutical industries. Anthocyanins provide several health benefits, showing potential to prevent damage and diseases caused by oxidative stress, protein glycation, and premature aging. New formulations enhancing benefits of standardized extract have been developed and green synthesis of metallic nanoparticles have attracted great interest. Techniques such as UV-Visible spectroscopy, Dynamic Light Scattering (DLS), and Scanning Electron Microscopy (SEM) were conducted to characterize silver nanoparticles (AgNPs) synthesized using AnthocyanOx® aqueous extract (EeAE). Antioxidant activity was assessed through DPPH radical scavenging, Ferric Reducing Antioxidant Power (FRAP), ABTS radical scavenging, and Oxygen Radical Absorbance Capacity (ORAC). Molecular docking analyses were conducted to evaluate molecular interactions. The characterization demonstrated AgNPs formation. Antioxidant evaluations showed high antioxidant activity for both EeAE and AgNPs. In silico assays demonstrated that anthocyanins interacted with all enzymes evaluated. These results represent an important indicator for the development and discovery of new nanostructured formulations using standardized extracts rich in anthocyanins extracted from E. edulis for food, cosmetic, and pharmaceutical industries.

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来源期刊

Food and Bioproducts Processing 工程技术-工程：化工

CiteScore

9.70

自引率

4.30%

发文量

115

审稿时长

24 days

期刊介绍： Official Journal of the European Federation of Chemical Engineering: Part C FBP aims to be the principal international journal for publication of high quality, original papers in the branches of engineering and science dedicated to the safe processing of biological products. It is the only journal to exploit the synergy between biotechnology, bioprocessing and food engineering. Papers showing how research results can be used in engineering design, and accounts of experimental or theoretical research work bringing new perspectives to established principles, highlighting unsolved problems or indicating directions for future research, are particularly welcome. Contributions that deal with new developments in equipment or processes and that can be given quantitative expression are encouraged. The journal is especially interested in papers that extend the boundaries of food and bioproducts processing. The journal has a strong emphasis on the interface between engineering and food or bioproducts. Papers that are not likely to be published are those: • Primarily concerned with food formulation • That use experimental design techniques to obtain response surfaces but gain little insight from them • That are empirical and ignore established mechanistic models, e.g., empirical drying curves • That are primarily concerned about sensory evaluation and colour • Concern the extraction, encapsulation and/or antioxidant activity of a specific biological material without providing insight that could be applied to a similar but different material, • Containing only chemical analyses of biological materials.