Effect of non-neurological complications on the functional outcome of patients with ruptured intracranial aneurysms

IF 1.5 4区医学 Q4 CLINICAL NEUROLOGY

Neurochirurgie Pub Date : 2025-04-03 DOI:10.1016/j.neuchi.2025.101663

Diego A. Ortega Moreno, Ibrahim Almulhim, Jerry C. Ku, Nicole Cancelliere, Danilo B. Diestro, Julian Spears, Vitor Mendes Pereira

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引用次数: 0

Abstract

Background

Aneurysmal subarachnoid hemorrhage (aSAH) is a life-threatening pathology associated with significant neurological and non-neurological complications. While the impact of neurological factors has been extensively studied, the impact of non-neurological complications remains underexplored. This study aimed to assess the effect of non-neurological complications on hospital stay and functional outcomes of patients with ruptured intracranial aneurysms (IAs).

Methods

A retrospective cohort study assessed patients with ruptured IAs treated within a neurovascular program of a tertiary hospital between October 2019 and September 2023. Inclusion criteria were: ≥18 years old, confirmed aSAH, and available follow-up information. The primary outcome corresponded to non-excellent functional outcomes at 6- and 12-month follow-ups. Secondary outcomes included length of in-hospital and intensive care unit (ICU) stay. Multivariate logistic regression models, adjusted for age, sex, and baseline World Federation of Neurosurgical Societies (WFNS) scores, were conducted.

Results

A total of 220 patients were included in this study, with a mean age of 56.66 ± 13.79 years; 74.5% were female. The most prevalent non-neurological complications were isolated fever (56.4%), arrhythmias (44.1%), and urinary tract infections (38.6%). Patients with poor neurological presentation had a higher prevalence of non-neurological complications. Pneumonia, pulmonary embolism, hyperglycemia, as well as fever were associated with higher odds of non-excellent functional outcomes (mRS 2–6) at 6- and 12-month follow-ups.

Conclusions

Non-neurological complications significantly impact hospital stay and functional recovery in aSAH patients. Early diagnosis and intervention, as well as the implementation of comprehensive clinical algorithms, are crucial for improving long-term outcomes in patients with ruptured IAs.

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来源期刊

Neurochirurgie 医学-临床神经学

CiteScore

2.70

自引率

6.20%

发文量

100

审稿时长

29 days

期刊介绍： Neurochirurgie publishes articles on treatment, teaching and research, neurosurgery training and the professional aspects of our discipline, and also the history and progress of neurosurgery. It focuses on pathologies of the head, spine and central and peripheral nervous systems and their vascularization. All aspects of the specialty are dealt with: trauma, tumor, degenerative disease, infection, vascular pathology, and radiosurgery, and pediatrics. Transversal studies are also welcome: neuroanatomy, neurophysiology, neurology, neuropediatrics, psychiatry, neuropsychology, physical medicine and neurologic rehabilitation, neuro-anesthesia, neurologic intensive care, neuroradiology, functional exploration, neuropathology, neuro-ophthalmology, otoneurology, maxillofacial surgery, neuro-endocrinology and spine surgery. Technical and methodological aspects are also taken onboard: diagnostic and therapeutic techniques, methods for assessing results, epidemiology, surgical, interventional and radiological techniques, simulations and pathophysiological hypotheses, and educational tools. The editorial board may refuse submissions that fail to meet the journal''s aims and scope; such studies will not be peer-reviewed, and the editor in chief will promptly inform the corresponding author, so as not to delay submission to a more suitable journal. With a view to attracting an international audience of both readers and writers, Neurochirurgie especially welcomes articles in English, and gives priority to original studies. Other kinds of article - reviews, case reports, technical notes and meta-analyses - are equally published. Every year, a special edition is dedicated to the topic selected by the French Society of Neurosurgery for its annual report.