Visible-Light Photocatalytic Nucleophilic Addition of 4-Pyridylphosphonium Salts to CO2 and Carbonyl Compounds

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-03-24 DOI:10.1021/acs.orglett.5c0078610.1021/acs.orglett.5c00786

Wenwen Cui, Bin Li and Baiquan Wang*,

引用次数: 0

Abstract

A visible-light photocatalytic nucleophilic addition of 4-pyridylphosphonium salts to CO₂ and carbonyl compounds is reported. The reaction has mild reaction conditions, good functional group tolerance, and a wide range of substrates. Mechanistic studies show that the reaction may occur through the pyridylphosphonium salt radical anion, pyridyl radical, and pyridyl anion intermediates. By combination with C4–H phosphination, this method can be applied to the late-stage C–H functionalization of drugs containing a pyridine unit.

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4-吡啶基磷酸盐在CO2和羰基化合物上的可见光催化亲核加成反应

报道了4-吡啶基磷酸盐在CO2和羰基化合物上的可见光催化亲核加成反应。该反应反应条件温和，官能团耐受性好，底物范围广。机理研究表明，该反应可能通过吡啶基磷盐自由基阴离子、吡啶基自由基和吡啶基阴离子中间体发生。通过与C4-H磷酸化的结合，该方法可应用于含有吡啶单元的药物的后期C-H功能化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.