Tackling a textbook example of multistep enzyme catalysis with deep learning-driven design

IF 14.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cell Pub Date : 2025-04-03 DOI:10.1016/j.molcel.2025.03.012

Boje Ingwersen, Birte Höcker

引用次数: 0

Abstract

Enzyme design has struggled to emulate the complexity and catalytic proficiency of natural enzymes. Lauko et al.¹ show that with the help of deep learning, the design of serine hydrolases that rival nature’s ingenuity is possible.

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来源期刊

Molecular Cell 生物-生化与分子生物学

CiteScore

26.00

自引率

3.80%

发文量

389

审稿时长

1 months

期刊介绍： Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.