Antibody numbering schemes: advances, comparisons and tools for antibody engineering.

IF 2.6 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Zirui Zhu, Hossein Ashrafian, Navid Mohammadian Tabrizi, Emily Matas, Louisa Girard, Haowei Ma, Edouard C Nice
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引用次数: 0

Abstract

The evolution of antibody engineering has significantly enhanced the development of antibody-based therapeutics, enabling the creation of novel antibody formats tailored for specific applications. Since the introduction of the Kabat numbering scheme in 1977, various schemes have been developed and modified, forming the foundation for multiple antibody engineering projects. The tools associated with these schemes further facilitate the engineering process. However, discrepancies among current numbering schemes can lead to confusion. This study examines various numbering schemes and related tools, providing new insights into antibody variable domains. Improved understanding of antibody numbering and related tools holds significant potential for more precise and efficient antibody design, thereby advancing antibody-based therapeutics and diagnostics.

抗体编号方案:抗体工程的进展、比较和工具。
抗体工程的发展极大地促进了基于抗体的治疗方法的发展,使为特定应用量身定制的新型抗体格式成为可能。自1977年引入Kabat编号方案以来,各种方案被开发和修改,形成了多个抗体工程项目的基础。与这些方案相关联的工具进一步促进了工程过程。然而,当前编号方案之间的差异可能导致混淆。本研究考察了各种编号方案和相关工具,为抗体可变域提供了新的见解。提高对抗体编号和相关工具的理解具有更精确和有效的抗体设计的巨大潜力,从而推进基于抗体的治疗和诊断。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Protein Engineering Design & Selection
Protein Engineering Design & Selection 生物-生化与分子生物学
CiteScore
3.30
自引率
4.20%
发文量
14
审稿时长
6-12 weeks
期刊介绍: Protein Engineering, Design and Selection (PEDS) publishes high-quality research papers and review articles relevant to the engineering, design and selection of proteins for use in biotechnology and therapy, and for understanding the fundamental link between protein sequence, structure, dynamics, function, and evolution.
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