The global, regional, and national burden of Invasive Non-typhoidal Salmonella (iNTS): An analysis from the Global Burden of Disease Study 1990-2021.

IF 3.4 2区医学 Q1 PARASITOLOGY

PLoS Neglected Tropical Diseases Pub Date : 2025-04-01 DOI:10.1371/journal.pntd.0012960

Yunjuan He, Qingqing Jia, Kang Cai, Shanshan Xu, Huajun Li, Qiuling Xie, Yushu Qiu, Liya Zhang, Xianting Jiao

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引用次数: 0

Abstract

Objectives: Invasive Non-typhoidal Salmonella (iNTS) can cause serious, life-threatening, and invasive infections, posing great challenges to public health. We aimed to systematically review the burden of iNTS disease based on Global Burden of Diseases (GBD) 2021.

Methods: We extracted data for the incidence, death, and disability-adjusted life-years (DALYs) associated with iNTS from GBD 2021, providing an overview of its epidemiology while examining trends from 1990 to 2021. Additionally, we decomposed changes of iNTS-related burden, and quantified cross-country inequalities.

Results: GBD 2021 estimated 509976(95%UI,413361 to 606167) incident cases of iNTS worldwide in 2021, with the most cases and highest age-standardized rate (ASR) in Western Sub-Saharan Africa. The low SDI region had the most cases of iNTS in 2021. The incidence and DALYs rates were highest in the Low SDI region. Among all age groups, the incidence, death, and DALYs rate of iNTS were primarily concentrated among the following age groups: <1 year, 1-4 years, 5-9 years, 10-14 years, and 15-19 years. The highest rates were observed in the <1-year group. The results of joinpoint regression analysis revealed that the global burden of iNTS increased overall from 1990 to 2005, followed by notable decrease from 2005 to 2021 at varying rates. Decomposition analysis found that population growth (103.93%) and epidemiological change (48.34%) were responsible for motivating the changes in iNTS global burden. Cross-country inequality analysis revealed that the SDI-related inequalities were moderated from 1990 to 2021.

Conclusions: The global burden of iNTS is still high, and the distribution patterns vary across different countries and territories. The global burden of iNTS was primarily noteworthy among children and adolescents, with the highest burden among infants. The changes in the iNTS burden were primarily driven by population growth and epidemic transition. Despite varying iNTS burdens across different SDI regions, SDI-related inequalities across countries became moderated gradually over time. This study reported the global disease burden and temporal trends of iNTS disease, and underscores the need for age- and region-specific strategies to mitigate the corresponding global burden.

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侵袭性非伤寒沙门氏菌（iNTS）的全球、区域和国家负担：来自1990-2021年全球疾病负担研究的分析

目的：侵袭性非伤寒沙门氏菌（iNTS）可引起严重的、危及生命的侵袭性感染，对公共卫生构成巨大挑战。我们的目的是基于2021年全球疾病负担（GBD）系统地回顾iNTS疾病的负担。方法：我们从GBD 2021中提取了与iNTS相关的发病率、死亡率和残疾调整生命年（DALYs）的数据，概述了其流行病学，同时检查了1990年至2021年的趋势。此外，我们还分解了int相关负担的变化，并量化了跨国不平等。结果：GBD 2021估计2021年全球iNTS病例为509976例（95%UI，413361至606167例），其中撒哈拉以南非洲西部病例最多，年龄标准化率（ASR）最高。2021年，低SDI地区的iNTS病例最多。低SDI地区的发病率和DALYs率最高。在所有年龄组中，iNTS的发病率、死亡率和DALYs率主要集中在以下年龄组：结论：iNTS的全球负担仍然很高，不同国家和地区的分布模式存在差异。全球iNTS负担主要在儿童和青少年中值得注意，其中婴儿负担最高。全国综合医疗服务负担的变化主要是由人口增长和流行病过渡造成的。尽管不同SDI地区的iNTS负担不同，但随着时间的推移，各国与SDI相关的不平等现象逐渐得到缓解。本研究报告了全球疾病负担和iNTS疾病的时间趋势，并强调需要制定针对特定年龄和区域的战略来减轻相应的全球负担。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

PLoS Neglected Tropical Diseases PARASITOLOGY-TROPICAL MEDICINE

自引率

10.50%

发文量

723

期刊介绍： PLOS Neglected Tropical Diseases publishes research devoted to the pathology, epidemiology, prevention, treatment and control of the neglected tropical diseases (NTDs), as well as relevant public policy. The NTDs are defined as a group of poverty-promoting chronic infectious diseases, which primarily occur in rural areas and poor urban areas of low-income and middle-income countries. Their impact on child health and development, pregnancy, and worker productivity, as well as their stigmatizing features limit economic stability. All aspects of these diseases are considered, including: Pathogenesis Clinical features Pharmacology and treatment Diagnosis Epidemiology Vector biology Vaccinology and prevention Demographic, ecological and social determinants Public health and policy aspects (including cost-effectiveness analyses).