Tumor Immunotherapy Targeting B7-H3: From Mechanisms to Clinical Applications.

IF 6.2 Q1 IMMUNOLOGY
ImmunoTargets and Therapy Pub Date : 2025-03-27 eCollection Date: 2025-01-01 DOI:10.2147/ITT.S507522
Yining Guo, Xudong Wang, Chen Zhang, Weiwu Chen, Yutian Fu, Yanlan Yu, Yicheng Chen, Tiejuan Shao, Jie Zhang, Guoqing Ding
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引用次数: 0

Abstract

B7-H3 (CD276) is an immune checkpoint from the B7 family of molecules and is abnormally expressed in tumor cells as a co-inhibitory molecule to promote tumor progression. Within the tumor microenvironment (TME), B7-H3 promotes tumor progression by impairing the T cell response, driving the polarization of tumor-associated macrophages (TAMs) to M2 phenotype, and inhibiting the function of other immune cells. In addition, B7-H3 promotes tumor cell proliferation, migration, invasion, metabolism disorder, angiogenesis, and resistance to treatment to promote tumor progression through its non-immunological functions. Immunotherapy targeting B7-H3, as well as combinations with other immune checkpoint therapies, have shown certain efficacy. In this review, we synthesizes the expression of B7-H3 and its mechanism to promote tumor progression through inducing immunomodulation and non-immunological functions, as well as its role of B7-H3 in tumor therapy, aiming to provide a reference for the clinical treatment of tumors.

以 B7-H3 为靶点的肿瘤免疫疗法:从机制到临床应用。
B7- h3 (CD276)是来自B7分子家族的免疫检查点,在肿瘤细胞中异常表达为促进肿瘤进展的共抑制分子。在肿瘤微环境(tumor microenvironment, TME)中,B7-H3通过损害T细胞应答、驱动肿瘤相关巨噬细胞(tumor-associated macrophages, tam)向M2表型极化以及抑制其他免疫细胞的功能来促进肿瘤进展。此外,B7-H3通过其非免疫功能促进肿瘤细胞增殖、迁移、侵袭、代谢紊乱、血管生成和对治疗的抵抗,促进肿瘤进展。针对B7-H3的免疫治疗以及与其他免疫检查点疗法的联合治疗已显示出一定的疗效。本文综述了B7-H3的表达及其通过诱导免疫调节和非免疫功能促进肿瘤进展的机制,以及B7-H3在肿瘤治疗中的作用,旨在为肿瘤的临床治疗提供参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
16.50
自引率
0.00%
发文量
7
审稿时长
16 weeks
期刊介绍: Immuno Targets and Therapy is an international, peer-reviewed open access journal focusing on the immunological basis of diseases, potential targets for immune based therapy and treatment protocols employed to improve patient management. Basic immunology and physiology of the immune system in health, and disease will be also covered.In addition, the journal will focus on the impact of management programs and new therapeutic agents and protocols on patient perspectives such as quality of life, adherence and satisfaction.
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