Role of comprehensive geriatric assessment, G8 and HOF score: how can we predict mortality in older patients with hematological malignancies?

Abstract

Comprehensive geriatric assessment (CGA) is recommended for the evaluation of older patients with hematological malignancies. We investigated the association between CGA and mortality during hospitalization and at 1-year follow-up. Frailty was assessed by FRAIL scale, nutritional status by Mini-Nutritional Assessment-Short Form (MNA-SF), sarcopenia risk status by SARC-F. The Haema-Oncology Frailty (HOF) and Geriatric-8 (G8) scores were calculated prior to treatment. Most of the participants had malnutrition or risk of malnutrition based on the MNA-SF score. Half of the participants had risk of sarcopenia (n = 42, 50%). According to the FRAIL score, 51.2% (n:43) of the patients were frail and 38.1% (n:32) were pre-frail. Frailty was identified in 42.9% (n = 36) (HOF scores). Frailty (p = 0.007) and sarcopenia risk (p = 0.044) were linked to in-hospital mortality, the risk of 1-year mortality increased with higher HOF scores (p = 0.040). Findings from this study support the use of the FRAIL scale, SARC-F, and HOF score in clinical settings.