Yaqing Wen, Issa Ali Issa, Li Lei, Chuhan Fu, Shu Zhou, Keyi Zhang, Jiangfeng Huang, Jing Chen, Qinghai Zeng, Ling Jiang
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引用次数: 0
Abstract
Introduction: Vitiligo is a prevalent depigmentation disorder. Due to the depigmentation and treatments, skin function of patients with vitiligo may be affected, manifested by changes in the stratum corneum (SC) hydration, sebum and elasticity. However, few researchers have paid attention to the skin condition of vitiligo after treatment.
Methods: A cross-sectional study was conducted. SC hydration, sebum and elasticity of 154 vitiligo lesions were measured to evaluate skin function after topical treatments and phototherapy and investigate potential influencing factors.
Results: Treated vitiligo lesions exhibited significantly lower SC hydration and elasticity compared to normal skin, while sebum levels were notably higher. Combined treatments-specifically, 308-nm excimer laser with topical calcineurin inhibitors (TCI) and either topical corticosteroids (TCS) or compound kaliziran tincture (CKT), as well as 308-nm excimer laser with TCI, TCS and CKT-resulted in reduced SC hydration and elasticity as well as increased sebum levels in lesions. Notably, the 308-nm excimer laser had a greater effect on increasing sebum on lesions.
Conclusion: Our findings indicate that skin barrier damage and decreased elasticity occur in patients with vitiligo after topical treatments and phototherapy. This underscores the need for enhanced skin management and appropriate post-treatment skin care for patients with vitiligo.
期刊介绍：
Dermatology and Therapy is an international, open access, peer-reviewed, rapid publication journal (peer review in 2 weeks, published 3–4 weeks from acceptance). The journal is dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of dermatological therapies. Studies relating to diagnosis, pharmacoeconomics, public health and epidemiology, quality of life, and patient care, management, and education are also encouraged.
Areas of focus include, but are not limited to all clinical aspects of dermatology, such as skin pharmacology; skin development and aging; prevention, diagnosis, and management of skin disorders and melanomas; research into dermal structures and pathology; and all areas of aesthetic dermatology, including skin maintenance, dermatological surgery, and lasers.
The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/case series, trial protocols, and short communications. Dermatology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an International and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of quality research, which may be considered of insufficient interest by other journals. The journal appeals to a global audience and receives submissions from all over the world.
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