Risk of Depression and Anxiety in Those Who Gave Birth to Children Who Developed Invasive Group B Streptococcal Disease: A Population-Based Cohort Study.

IF 3.4 2区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Clinical Epidemiology Pub Date : 2025-03-28 eCollection Date: 2025-01-01 DOI:10.2147/CLEP.S506809

Erzsébet Horváth-Puhó, Jaya Chandna, Proma Paul, Claire A Wilson, Henrik T Sørensen, Joy E Lawn

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引用次数: 0

Abstract

Background: Mental disorders such as depression and anxiety are common for women of reproductive age and impact pregnancy and parenting. Invasive Group B Streptococcus disease (iGBS) is a leading cause of neonatal morbidity and mortality worldwide. Little is known about the short and long-term risk of common mental disorders in birthing parents whose infants had iGBS in the first 89 days after birth. We aimed to examine the risk of depression and anxiety in birthing parents with iGBS-affected infants in a cohort study with prospectively collected data from Danish registries.

Materials and methods: Using Danish healthcare registries from 1997 to 2018, we obtained data on iGBS-affected children and their birthing parents. A comparison cohort was randomly sampled (1:50) through risk-set sampling, and matched on persons' age, year of child´s birth, and parity. The risk of using antidepressant medicines and depression or anxiety diagnosis was analyzed with cumulative incidence function and in Cox proportional hazards regression models.

Results: During the study period, we identified 1,552 women with iGBS-affected child and 76,879 matched comparators. During a median follow-up of 9∙9 years, the cumulative incidence of antidepressants use among birthing parents with iGBS-affected children was 31% (95% confidence interval, CI: 28-34%), as compared with 29% (95% CI: 28-30%) among members of the comparison cohort (hazard ratio 1∙12 [95% CI: 1∙01-1∙25]). A 16% increase in the rate of diagnosed depression or anxiety was observed in the overall follow-up period.

Conclusion: Our findings provide evidence of a slightly increased risk of antidepressant use and diagnosed depression or anxiety in parents who gave birth to children with a history of iGBS compared to a matched cohort of birthing parents whose infants did not develop iGBS. Our findings highlight the importance of addressing the mental health needs of birthing parents affected by their children' iGBS.

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患有侵袭性B组链球菌疾病的儿童的抑郁和焦虑风险：一项基于人群的队列研究

背景：精神障碍如抑郁和焦虑在育龄妇女中很常见，并影响怀孕和育儿。侵袭性B族链球菌病（iGBS）是全球新生儿发病率和死亡率的主要原因。对于婴儿在出生后89天内患有iGBS的父母患常见精神障碍的短期和长期风险知之甚少。我们的目的是在一项队列研究中研究igbs患儿父母的抑郁和焦虑风险，该队列研究前瞻性地收集了丹麦登记处的数据。材料和方法：使用1997年至2018年的丹麦医疗保健登记处，我们获得了igbs患儿及其出生父母的数据。通过风险集抽样随机抽取比较队列（1:50），并根据人的年龄、出生年份和胎次进行匹配。采用累积发生率函数和Cox比例风险回归模型分析使用抗抑郁药物和抑郁或焦虑诊断的风险。结果：在研究期间，我们确定了1552名患有igbs患儿的妇女和76879名匹配的比较者。在中位9∙9年的随访期间，患有igbs患儿的生父母使用抗抑郁药的累积发生率为31%(95%可信区间，CI: 28-34%)，而对照组为29% (95% CI: 28-30%)（风险比为1∙12 [95% CI: 1∙01-1∙25]）。在整个随访期间，观察到诊断为抑郁症或焦虑症的比率增加了16%。结论：我们的研究结果提供了证据，与没有发生iGBS的父母相比，有iGBS病史的父母使用抗抑郁药和诊断为抑郁或焦虑的风险略有增加。我们的研究结果强调了解决受孩子iGBS影响的分娩父母的心理健康需求的重要性。

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来源期刊

Clinical Epidemiology Medicine-Epidemiology

CiteScore

6.30

自引率

5.10%

发文量

169

审稿时长

16 weeks

期刊介绍： Clinical Epidemiology is an international, peer reviewed, open access journal. Clinical Epidemiology focuses on the application of epidemiological principles and questions relating to patients and clinical care in terms of prevention, diagnosis, prognosis, and treatment. Clinical Epidemiology welcomes papers covering these topics in form of original research and systematic reviews. Clinical Epidemiology has a special interest in international electronic medical patient records and other routine health care data, especially as applied to safety of medical interventions, clinical utility of diagnostic procedures, understanding short- and long-term clinical course of diseases, clinical epidemiological and biostatistical methods, and systematic reviews. When considering submission of a paper utilizing publicly-available data, authors should ensure that such studies add significantly to the body of knowledge and that they use appropriate validated methods for identifying health outcomes. The journal has launched special series describing existing data sources for clinical epidemiology, international health care systems and validation studies of algorithms based on databases and registries.