Clinical Application of Clot Waveform Analysis.

IF 2.3 4区 医学 Q2 HEMATOLOGY
Hideo Wada, Katsuya Shiraki, Yuhko Ichikawa, Takeshi Matsumoto, Hideto Shimpo, Motomu Shimaoka
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引用次数: 0

Abstract

Clot waveform analysis (CWA) involves an analysis of the activated partial thromboplastin time (CWA-APTT), diluted prothrombin time (CWA-dPT), and small amount of thrombin time (CWA-sTT), and clot fibrinolysis waveform analysis (CFWA). CWA was evaluated in order to propose its clinical application. CWA exhibits an abnormal waveform, as well as peak times and heights in its derivative curves. Although the CWA-APTT is frequently examined and is useful for diagnosing clotting deficiency, it has several limitations. Therefore, modified CWAs have been proposed for clinical application. CWA-dPT (small amount of tissue factor-induced FIX activation; sTF/FIXa) can detect hypercoagulability. CWA-sTT reflects thrombin burst and evaluates hemostatic abnormalities in patients treated with emicizumab. CFWA is a variant of CWA-APTT that includes a small amount of tissue-type plasminogen activator, indicating both clotting and fibrinolysis. The CWA-APTT and modified CWA should be further investigated in various diseases for many applications in the clinical setting, including the monitoring of hemophilia patients and patients receiving anticoagulant therapy, and the differential diagnosis of diseases.

血块波形分析的临床应用。
凝块波形分析(CWA)包括活化部分凝血活酶时间(CWA- aptt)、稀释凝血酶原时间(CWA- dpt)和少量凝血酶时间(CWA- stt)的分析,以及凝块纤溶波形分析(CFWA)。对CWA进行评价,提出其临床应用价值。CWA呈现异常波形,其导数曲线出现峰值时间和峰值高度。虽然CWA-APTT经常被检查,对诊断凝血缺陷很有用,但它有一些局限性。因此,提出了改良的CWAs用于临床应用。CWA-dPT(少量组织因子诱导FIX激活;sTF/FIXa)可检测高凝性。CWA-sTT反映凝血酶爆发和评估使用emicizumab治疗的患者的止血异常。CFWA是CWA-APTT的一种变体,包括少量的组织型纤溶酶原激活剂,表明凝血和纤溶。CWA- aptt和改良后的CWA在各种疾病中的临床应用有待进一步研究,包括血友病患者和接受抗凝治疗的患者的监测,以及疾病的鉴别诊断。
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来源期刊
CiteScore
4.40
自引率
3.40%
发文量
150
审稿时长
2 months
期刊介绍: CATH is a peer-reviewed bi-monthly journal that addresses the practical clinical and laboratory issues involved in managing bleeding and clotting disorders, especially those related to thrombosis, hemostasis, and vascular disorders. CATH covers clinical trials, studies on etiology, pathophysiology, diagnosis and treatment of thrombohemorrhagic disorders.
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