Elemental Boron-10 Nanoparticles Synthesized by Laser Fragmentation for Boron Neutron Capture Therapy: In Vitro Experiments

IF 0.6 4区 物理与天体物理 Q4 PHYSICS, MULTIDISCIPLINARY
A. I. Kasatova, K. S. Kuzmina, D. A. Kasatov, E. V. Barmina, K. O. Aiyyzhy, P. A. Kotelnikova, M. S. Grigoryeva, D. S. Petrunya, E. L. Zavjalov, S. Yu. Taskaev, S. M. Deyev, I. N. Zavestovskaya
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Abstract

Elemental boron-10 nanoparticles synthesized by laser fragmentation of micropowder in isopropanol are used for the first time as a boron-containing agent for boron neutron capture therapy. The study is conducted on human cell cultures U87, BT474, and BJ-5TA. It is found that these nanoparticles are nontoxic to all three cell cultures at boron-10 concentrations required for successful boron neutron capture therapy. The cell cultures are pre-incubated with nanoparticles and then irradiated for 30 min with a beam of epithermal neutrons generated by the VITA accelerator source (BINP SB RAS, Novosibirsk). Using in vitro study results (MTT assay and clonogenic analysis), an enhancement of the therapeutic effect of boron neutron capture therapy is observed.

Abstract Image

用于硼中子俘获疗法的激光碎裂法合成的元素硼-10 纳米粒子:体外实验
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来源期刊
Bulletin of the Lebedev Physics Institute
Bulletin of the Lebedev Physics Institute PHYSICS, MULTIDISCIPLINARY-
CiteScore
0.70
自引率
25.00%
发文量
41
审稿时长
6-12 weeks
期刊介绍: Bulletin of the Lebedev Physics Institute is an international peer reviewed journal that publishes results of new original experimental and theoretical studies on all topics of physics: theoretical physics; atomic and molecular physics; nuclear physics; optics; lasers; condensed matter; physics of solids; biophysics, and others.
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