Relationship Between the Elastic Modulus of the Novel Pedicle Screw-Plate System and Biomechanical Properties Under Osteoporotic Condition: A Power-Law Regression Analysis Based on Parametric Finite Element Simulations

IF 4.9 2区医学 Q1 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS

Computer methods and programs in biomedicine Pub Date : 2025-03-29 DOI:10.1016/j.cmpb.2025.108760

Kaibin Wang , Chongyi Wang , Haipeng Si , Yanwei Zhang , Shaowei Sang , Runtong Zhang , Wencan Zhang , Junfei Chen , Chen Liu , Kunpeng Li , Bingtao Hu , Xiangyu Lin , Yunze Feng , Qingyang Fu , Zhihao Kang , Mingyu Xu , Dingxin Zhang , Wanlong Xu , Le Li

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引用次数: 0

Abstract

Background and objective

The novel pedicle screw-plate system (NPSPS) is a new internal fixation method for the thoracic spine that we proposed, which has demonstrated effectiveness through clinical practice and biomechanical testing. Nevertheless, the optimal elastic modulus of NPSPS (NPSPS-E) remains debated, particularly for osteoporosis patients. We propose a more efficient method to predict the biomechanical effects of NPSPS across varying elastic moduli in osteoporosis using parametric finite element (FE) analysis, establishing the regression relationship between NPSPS-E and biomechanical properties.

Methods

An FE surgical model of NPSPS under osteoporotic conditions was developed. The NPSPS-E was linearly varied from 3.6 GPa (polyether ether ketone) to 110 GPa (titanium alloy). Using power-law regression analysis, a functional equation was established to correlate NPSPS-E with biomechanical properties under osteoporotic condition.

Results

Power-law equations and regression models were successfully established between NPSPS-E and biomechanical prediction indices under osteoporotic condition (P<0.0001). As NPSPS-E increased, the range of motion (ROM) of the T8-T10 spinal segments decreased from 0.51°-4.06° to 0.24°-1.45°. The mean von Mises stress in the T8-T10 vertebrae declined from 1.36 MPa-2.03 MPa to 1.15 MPa-1.79 MPa. Concurrently, the stress shielding ratios and the total stress ratios of the NPSPS increased from 3.66%-48.07% and 13.96%-26.96% to 10.70%-56.20% and 52.62%-64.40%, respectively.

Conclusion

The functional equations derived from these models serve as a predictive tool to directly estimate the biomechanical effects of NPSPS across a range of elastic modulus under osteoporotic conditions, thereby facilitating the design and optimization of NPSPS materials.

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来源期刊

Computer methods and programs in biomedicine 工程技术-工程：生物医学

CiteScore

12.30

自引率

6.60%

发文量

601

审稿时长

135 days

期刊介绍： To encourage the development of formal computing methods, and their application in biomedical research and medical practice, by illustration of fundamental principles in biomedical informatics research; to stimulate basic research into application software design; to report the state of research of biomedical information processing projects; to report new computer methodologies applied in biomedical areas; the eventual distribution of demonstrable software to avoid duplication of effort; to provide a forum for discussion and improvement of existing software; to optimize contact between national organizations and regional user groups by promoting an international exchange of information on formal methods, standards and software in biomedicine. Computer Methods and Programs in Biomedicine covers computing methodology and software systems derived from computing science for implementation in all aspects of biomedical research and medical practice. It is designed to serve: biochemists; biologists; geneticists; immunologists; neuroscientists; pharmacologists; toxicologists; clinicians; epidemiologists; psychiatrists; psychologists; cardiologists; chemists; (radio)physicists; computer scientists; programmers and systems analysts; biomedical, clinical, electrical and other engineers; teachers of medical informatics and users of educational software.